Department of Obstetrics & Gynecology, Duke University School of Medicine, DUMC 3084, Durham, NC, 27710, USA.
Int Urogynecol J. 2021 Jul;32(7):1971-1976. doi: 10.1007/s00192-021-04797-9. Epub 2021 Apr 17.
The purpose of this article is to understand that the majority of studies investigating the role of risk factors for maternal birth trauma and pelvic floor disorders are designed using causal inferential statistical methods and have not been designed to investigate the more useful goal of clinical prediction.
A review of the literature was conducted to describe notable causal and predictive associations between risk factors and maternal birth trauma outcomes. Examples were obtained to illustrate and contrast differences in clinical usefulness between causal and predictive models.
Effects of pregnancy and childbirth on the risk of maternal birth trauma outcomes and subsequent pelvic floor disorders are an area of profound investigation. Numerous observational studies provide evidence that pregnancy and childbirth play a causal role in the increasing prevalence of these outcomes, and clinicians must rely on this observational evidence to guide decisions about preventing maternal birth trauma and pelvic floor disorders. However, there are important differences between the design and evaluation of models for a predictive context including: study design goals, inclusion or exclusion of candidate risk factors, model evaluation and the additional need to assess model error.
This article contrasts how causal and predictive modeling approaches are different and argues that indiscriminately modeling risk factors for birth trauma and pelvic floor disorder outcomes is costly to women.
本文旨在了解大多数研究调查产妇分娩创伤和盆底功能障碍风险因素的作用是使用因果推理统计方法设计的,而不是为了研究更有用的临床预测目标。
对文献进行综述,以描述风险因素与产妇分娩创伤结局之间的显著因果和预测关联。举例说明了因果和预测模型在临床实用性方面的差异。
妊娠和分娩对产妇分娩创伤结局和随后的盆底功能障碍的影响是一个深入研究的领域。许多观察性研究提供了证据,证明妊娠和分娩在这些结局的患病率增加中起着因果作用,临床医生必须依赖这一观察性证据来指导预防产妇分娩创伤和盆底功能障碍的决策。然而,预测性背景下模型的设计和评估之间存在重要差异,包括:研究设计目标、候选风险因素的纳入或排除、模型评估以及额外需要评估模型误差。
本文对比了因果和预测建模方法的不同之处,并认为对分娩创伤和盆底功能障碍结局的风险因素进行不加区分的建模对女性来说代价高昂。