Themeli Maria, Spyridonidis Alexandros
Hematology Division, BMT Unit, University Hospital of Patras, Rio 26500, Greece.
Int J Mol Sci. 2012 Nov 27;13(12):15813-25. doi: 10.3390/ijms131215813.
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) in humans, following hematoablative treatment, results in biological chimeras. In this case, the transplanted hematopoietic, immune cells and their derivatives can be considered the donor genotype, while the other tissues are the recipient genotype. The first sequel, which has been recognized in the development of chimerical organisms after allo-HSCT, is the graft versus host (GvH) reaction, in which the new developed immune cells from the graft recognize the host's epithelial cells as foreign and mount an inflammatory response to kill them. There is now accumulating evidence that this chronic inflammatory tissue stress may contribute to clinical consequences in the transplant recipient. It has been recently reported that host epithelial tissue acquire genomic alterations and display a mutator phenotype that may be linked to the occurrence of a GvH reaction. The current review discusses existing data on this recently discovered phenomenon and focuses on the possible pathogenesis, clinical significance and therapeutic implications.
人类进行清髓性治疗后接受异基因造血干细胞移植（allo-HSCT）会产生生物嵌合体。在这种情况下，移植的造血、免疫细胞及其衍生物可被视为供体基因型，而其他组织则为受体基因型。异基因造血干细胞移植后嵌合体生物发育过程中首先被认识到的后果是移植物抗宿主（GvH）反应，即移植物中新发育的免疫细胞将宿主上皮细胞识别为外来物并引发炎症反应以杀死它们。现在有越来越多的证据表明，这种慢性炎症组织应激可能导致移植受者出现临床后果。最近有报道称，宿主上皮组织会发生基因组改变并表现出突变表型，这可能与GvH反应的发生有关。本综述讨论了关于这一最新发现现象的现有数据，并重点关注其可能的发病机制、临床意义和治疗意义。
