Yue Xiaoni, Utsunomiya Hiroki, Akahira Jun-Ichi, Suzuki Fumihiko, Ito Kiyoshi, Nagase Satoru, Sasano Hironobu, Yaegashi Nobuo
Departments of Obstetrics and Gynecology, Graduate School of Medicine, Tohoku University, Sendai 980-8574, Japan ; ; Department of Obstetrics and Gynecology, Fudan University, Shanghai 042465, P.R. China.
Oncol Lett. 2013 Mar;5(3):835-839. doi: 10.3892/ol.2012.1094. Epub 2012 Dec 28.
We analyzed the expression of the steroid and xenobiotic receptor (SXR) in human uterine sarcomas and evaluated its clinical significance. Forty-seven cases with archival specimens were examined for SXR expression using immunohistochemistry. All cases were scored using a semi-quantitative histological scoring (HSCORE) method. Specimens with a HSCORE >40 were regarded as SXR-positive. Various clinicopathological variables, including the expression status of estrogen receptor (ER)-α, progesterone receptor (PR) and Ki67 (MIB-1) were examined. The mean SXR HSCOREs of carcinosarcoma (CS) and leiomyosarcoma (LMS) were 9.13 and 23.6, respectively, and SXR-positive rates were 3 out of 24 (12.5%) and 4 out of 17 (23.5%), respectively. SXR was not detected in endometrial stromal sarcoma (ESS). In CS cases, significant differences were detected between the expression of SXR and age and disease stages. There was no significant correlation between SXR-positive status and either disease-free survival or overall survival. Our results support an association between SXR and malignant behavior. Our results show that overexpression of SXR may represent a useful marker to identify patients with advanced-stage CS. In addition, our results showed that SXR may aid in the diagnosis of uterine sarcomas.
我们分析了类固醇和外源性物质受体（SXR）在人子宫肉瘤中的表达，并评估了其临床意义。使用免疫组织化学方法对47例存档标本进行SXR表达检测。所有病例均采用半定量组织学评分（HSCORE）方法进行评分。HSCORE>40的标本被视为SXR阳性。检测了各种临床病理变量，包括雌激素受体（ER）-α、孕激素受体（PR）和Ki67（MIB-1）的表达状态。癌肉瘤（CS）和平滑肌肉瘤（LMS）的平均SXR HSCORE分别为9.13和23.6，SXR阳性率分别为24例中的3例（12.5%）和17例中的4例（23.5%）。子宫内膜间质肉瘤（ESS）中未检测到SXR。在CS病例中，SXR表达与年龄和疾病分期之间存在显著差异。SXR阳性状态与无病生存期或总生存期之间无显著相关性。我们的结果支持SXR与恶性行为之间的关联。我们的结果表明，SXR的过表达可能是识别晚期CS患者的有用标志物。此外，我们的结果表明，SXR可能有助于子宫肉瘤的诊断。
