Department of Marketing, University of Groningen, Groningen, The Netherlands.
Clin Pharmacol Ther. 2013 Apr;93(4):360-5. doi: 10.1038/clpt.2012.262. Epub 2012 Dec 27.
Serious safety issues relating to drugs are communicated to health-care professionals via Direct Health-Care Professional Communications (DHPCs). We explored which characteristics determined the impact of DHPCs issued in the Netherlands for ambulatory-care drugs (2001-2008). With multiple linear regression, we examined the impact on the relative change in new drug use post-DHPC of the following: time to DHPC, trend in use, degree of innovation, specialist drug, first/repeated DHPC, DHPC template, and type of safety issue. DHPCs have less impact on use of specialist drugs than nonspecialist drugs (P < 0.05). The DHPCs' impact increased after availability of a template emphasizing the main problem (P < 0.05), and for safety issues with a risk of death and/or disability (both P < 0.05) (adjusted R² = 0.392). Risk communication can be effective, specifically in case of well-structured information, and very serious safety issues. Effectiveness may improve by tailoring DHPCs and adding other communication channels, for example for drugs that are increasingly being used.
与药物相关的严重安全问题通过直接医疗保健专业人员通讯（DHPC）传达给医疗保健专业人员。我们探讨了哪些特征决定了荷兰为门诊药物（2001-2008 年）发布的 DHPC 的影响。我们使用多元线性回归，研究了以下因素对 DHPC 后新药使用的相对变化的影响：DHPC 时间、使用趋势、创新程度、专科药物、首次/重复 DHPC、DHPC 模板以及安全问题类型。DHPC 对专科药物的使用影响小于非专科药物（P < 0.05）。在提供强调主要问题的模板后，DHPC 的影响增加（P < 0.05），并且对于具有死亡和/或残疾风险的安全问题也是如此（均 P < 0.05）（调整后的 R²=0.392）。风险沟通可以是有效的，特别是在信息结构良好且安全问题非常严重的情况下。通过定制 DHPC 并添加其他沟通渠道，例如对于越来越多地使用的药物，可能会提高有效性。
