Department of Clinical Pharmacology, Graduate School of Medical Sciences, University Medical Center Groningen, University of Groningen, the Netherlands.
Clin Pharmacol Ther. 2012 May;91(5):838-45. doi: 10.1038/clpt.2011.308.
The effect of Direct Healthcare Professional Communications (DHPCs) informing health-care providers of serious drug safety issues has been questioned. The aim of this study was to evaluate the impact of DHPCs on drug use.Nationwide dispensing data for the period 2000–2008 for new users of 46 drugs with one or more DHPCs were assessed. Impact on short-term volume of use was evaluated with regression models, and the presence of long-term changes in use was evaluated with interrupted time series analyses incorporating preexisting trends. The short-term prescription level was lower post-DHPC in 28 (48.3%) of 58 cases. Twenty (34.5%) DHPCs resulted in long-term changes in use. A long-term mean reduction in use was observed in 26.7% of cases (95% confidence interval, −15.2 to −38.2%).Long-term changes in use were not significantly related to preexisting trends in use. Although short- and long-term decreases in use were observed after only half and a third of DHPCs, respectively, the decrease was substantial.
直接向医疗保健专业人员通报严重药物安全问题的直接医疗保健沟通（DHPC）的效果受到了质疑。本研究旨在评估 DHPC 对药物使用的影响。评估了 2000-2008 年期间 46 种药物的新使用者的全国配药数据，这些药物有一个或多个 DHPC。使用回归模型评估短期使用量的影响，并使用中断时间序列分析结合先前存在的趋势评估使用的长期变化。在 58 例中有 28 例（48.3%）的 DHPC 后短期处方量较低。20 例（34.5%）DHPC 导致使用发生长期变化。在 26.7%的情况下观察到使用的长期平均减少（95%置信区间，-15.2 至-38.2%）。使用的长期变化与先前存在的使用趋势无显著相关性。尽管只有一半和三分之一的 DHPC 分别观察到短期和长期使用减少，但减少幅度很大。
