Vieira Silva Cyntia Cristina, Ferraz Renato Ribeiro Nogueira, Fornari João Victor, Barnabe Anderson Sena
Universidade Nove de Julho, São Paulo, Brasil.
Rev Cubana Med Trop. 2012 Jan-Apr;64(1):22-6.
among the intestinal parasites, the helminthiasis occupies a prominent position in Brazil, since it worsens malnutrition and the gives rise to neurovegetative disorders. Helminths like Ascaris lumbricoides, Enterobius vermicularis, hookworm, Trichuris trichiura and Strongyloides stercoralis stand out due to several factors that modulate the immune response of individuals. Among the protozoa are Giardia lamblia, Entamoeba histolytica. E. dispar. Parasitic helminth antigens are important to stimulate the production of cytokines such as interleukin-4 and interleukin-5, which act through the induction of IgE synthesis and activation of eosinophils. Eosinophilia is usually detectable in pre-patent period of parasitism, initially linked to B lymphocytes, under the command of Th-2 lymphokines (IL-4 and IL-5), producing IgE in response to initial exposure to an antigen or allergen. Serum IgE high levels occur in tissue migration of larvae or harboring of parasites in tissues.
to determine the presence of eosinophils and IgE elevation in children with intestinal parasites.
high levels of IgE and eosinophils were observed in groups infected and not infected (allergic) to calculate the relative risk of intestinal parasites presumptive differentiated between protozoa and helminths and check what values of these indicators are observed in the epidemiological profile of the surveyed population.
the values obtained by calculating the relative risk for eosinophilia, compared with helminths and allergies was 11.71, but when examined by giardiasis compared with other diseases, the relative risk was 0.75. Since the comparison of helminths and giradiase, the relative risk was 27.33. Since IgE and its parameters were appropriate commit Helminth relative risk 0.39; Giardiasis had relative risk 8, 18 and Helminths compared with giardiasis had 0.03.
in this study it was possible to observe that helminthiasis is connected with cases of eosinophilia with alteration of IgE, which in turn contributes to the presence of IgE eosionofilia and has an effector response against helminths that provides the expulsion of its larvae.
在肠道寄生虫中，蠕虫病在巴西占据显著地位，因为它会加重营养不良并引发神经植物性紊乱。蛔虫、蛲虫、钩虫、鞭虫和粪类圆线虫等蠕虫因多种调节个体免疫反应的因素而格外突出。原生动物中有贾第虫、溶组织内阿米巴、迪氏内阿米巴。寄生蠕虫抗原对于刺激白细胞介素 -4 和白细胞介素 -5 等细胞因子的产生很重要，这些细胞因子通过诱导 IgE 合成和激活嗜酸性粒细胞发挥作用。嗜酸性粒细胞增多通常在寄生虫感染的潜伏期即可检测到，最初与 B 淋巴细胞有关，在 Th -2 淋巴细胞因子（IL -4 和 IL -5）的指挥下，针对初次接触抗原或过敏原产生 IgE。血清 IgE 高水平出现在幼虫组织迁移或寄生虫在组织中寄生时。
确定肠道寄生虫患儿中嗜酸性粒细胞的存在及 IgE 升高情况。
在感染组和未感染组（过敏组）观察到高水平的 IgE 和嗜酸性粒细胞，以计算肠道寄生虫（原生动物和蠕虫）之间推定的相对风险，并检查在被调查人群的流行病学概况中观察到这些指标的哪些值。
与蠕虫和过敏相比，计算嗜酸性粒细胞增多症相对风险所得的值为 11.71，但与其他疾病相比，当通过贾第虫病检查时，相对风险为 0.75。蠕虫与贾第虫病比较时，相对风险为 27.33。由于 IgE 及其参数适合计算蠕虫相对风险为 0.39；贾第虫病相对风险为 8.18，蠕虫与贾第虫病相比为 0.03。
在本研究中可以观察到，蠕虫病与嗜酸性粒细胞增多症病例以及 IgE 的改变有关，这反过来又导致 IgE 嗜酸性粒细胞增多的存在，并对蠕虫产生效应反应，促使其幼虫排出。
