Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla, and Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain.
Dev Neurosci. 2013;35(2-3):88-101. doi: 10.1159/000346155. Epub 2013 Feb 22.
Neuroinflammation is a complex immune response against the harmful effects of diverse stimuli within the central nervous system. Caspases are a family of intracellular cysteine proteases that mediate proteolytic events indispensable for transduction of signaling pathway-controlling biological phenomena such as apoptosis and inflammation. To date, 14 players have been identified in mammals. For many years, caspases were simply divided into 'apoptotic' and 'proinflammatory' caspases and this classification remains useful to some extent. However, increasing evidence indicates that many of these so-called apoptotic caspases also exert nonapoptotic functions. In addition, the role of certain members of the supposed inflammatory caspases in the inflammatory process per se has also been discussed. In this review, we highlight the role for 'apoptotic' and 'proinflammatory' caspases in the regulation of the inflammation response with a special focus on the central nervous system.
神经炎症是一种针对中枢神经系统内各种刺激的有害影响的复杂免疫反应。半胱天冬酶是一类细胞内半胱氨酸蛋白酶，可介导信号通路控制的生物学现象（如细胞凋亡和炎症）所必需的蛋白水解事件。迄今为止，在哺乳动物中已鉴定出 14 种成员。多年来，半胱天冬酶仅简单地分为“凋亡”和“促炎”半胱天冬酶，这种分类在某种程度上仍然有用。然而，越来越多的证据表明，许多所谓的凋亡半胱天冬酶也具有非凋亡功能。此外，某些假定的炎症半胱天冬酶成员在炎症过程本身中的作用也受到了讨论。在这篇综述中，我们强调了“凋亡”和“促炎”半胱天冬酶在炎症反应调节中的作用，特别关注中枢神经系统。
