40岁以下患者的尿路上皮癌。法国泌尿外科学会癌症委员会综述

[Urothelial carcinoma in patients under 40 years. Review of the cancer committee of the French Association of Urology].

作者信息

Compérat E, Camparo P, Larré S, Roupret M, Neuzillet Y, Pignot G, Quintens H, Houéde N, Roy C, Soulié M, Pfister C

机构信息

Service d'anatomie pathologique, université Pierre-et-Marie-Curie, groupe hospitalier Pitié-Salpêtrière Paris VI, 47-83, boulevard de l'Hôpital, 75013 Paris, France.

出版信息

Prog Urol. 2013 Mar;23(3):171-5. doi: 10.1016/j.purol.2012.12.001. Epub 2013 Jan 16.

DOI:10.1016/j.purol.2012.12.001

PMID:23446281

Abstract

INTRODUCTION

Urothelial carcinoma in young patients (<40 years) is rare. The only known risk factor is exposure to tobacco smoking and/or early active tobacco intoxication. No genetic predisposing factor seems to exist.

MATERIAL AND METHODS

A review of the literature was performed using PubMed database with a combination of the following keywords: urothelial carcinoma, young patients/adults, children, pediatrics, urothelium and neoplasm prognosis.

DISCUSSION

Urothelial carcinomas before the age of 20 years are non-invasive papillary lesions (papillary urothelial neoplasm of low malignant potential and non-invasive papillary urothelial carcinoma low grade or high grade) of excellent prognosis. Rare cases of infiltrating carcinomas have been described between 20 to 40 years; their histological and clinical aspects are close to those observed in usual urothelial carcinomas.

CONCLUSION

The management of urothelial carcinomas of patients under 40 years relies on the tumor grade and stage. Treatment of aggressive cases has to be curative from a clinical point of view, nevertheless conserving vital and reproducing functions.

摘要