Lions Eye Institute, Albany Medical College, Slingerlands, New York, U.S.A.
Ophthalmic Plast Reconstr Surg. 2013 Nov-Dec;29(6):e151-4. doi: 10.1097/IOP.0b013e3182831c6a.
Chronic cicatrizing conjunctivitis is a relatively uncommon condition resulting in significant ophthalmic morbidity, including keratoconjunctivitis sicca, cicatricial entropion, trichiasis, corneal scarring, significant discomfort, and visual loss. The potential causes of cicatrizing conjunctivitis are varied and include commonly encountered entities such as ocular cicatricial pemphigoid, Stevens-Johnson syndrome, and trachoma and many more rare causes which are particularly difficult to diagnose and treat and may not be familiar to the ophthalmologist. The authors herein present a case of chronic cicatrizing conjunctivitis, cicatricial entropion, and trichiasis caused by a rare entity called linear IgA bullous dermatosis. The case presentation conforms to the tenets of the Declaration of Helsinki and is Health Insurance Portability and Accountability Act compliant. This chronic dermatosis has a varied presentation, and the ophthalmic manifestations in particular have been infrequently described. This case demonstrates the benefits of immunohistochemistry in diagnosis and the difficulties in medical and surgical management of linear IgA bullous dermatosis while underscoring the lifelong difficulties in managing chronic inflammatory conditions causing ocular cicatrization.
慢性瘢痕性结膜炎是一种相对罕见的疾病，可导致严重的眼部疾病，包括干眼症、瘢痕性睑内翻、倒睫、角膜瘢痕、明显不适和视力丧失。瘢痕性结膜炎的潜在原因多种多样，包括常见的眼部瘢痕性类天疱疮、史蒂文斯-约翰逊综合征和沙眼等，以及许多更罕见的病因，这些病因特别难以诊断和治疗，可能不为眼科医生所熟悉。本文作者介绍了一例由一种罕见疾病线性 IgA 大疱性皮病引起的慢性瘢痕性结膜炎、瘢痕性睑内翻和倒睫。该病例报告符合赫尔辛基宣言的原则，并且符合《健康保险携带和责任法案》的规定。这种慢性皮肤病的表现形式多种多样，特别是眼部表现很少被描述。这个病例展示了免疫组织化学在诊断中的作用，以及在管理线性 IgA 大疱性皮病时在医学和手术方面的困难，同时强调了管理导致眼瘢痕形成的慢性炎症性疾病的终生困难。
