I. Scroyen, Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, CDG, Herestraat 49, Box 911, 3000 Leuven, Belgium, Tel.: +32 16 345775, Fax: +32 16 345990, E-mail:
Thromb Haemost. 2013 Oct;110(4):634-40. doi: 10.1160/TH12-11-0873. Epub 2013 Feb 28.
Obesity has become a world-wide epidemic and is associated with diseases such as diabetes, dyslipidaemia, cardiovascular disease and certain types of cancers. Understanding the adipose tissue developmental process, involving adipogenesis, angiogenesis and extracellular matrix remodelling, is therefore crucial to reveal the pathobiology of obesity. Experimental mouse models are extensively used to gain new insights into these processes and to evaluate the role of new key players, in particular proteolytic system components, in adipose tissue development and obesity. In this paper, we will review available in vitro and in vivo murine models of obesity and discuss their value in understanding the mechanisms contributing to obesity.
肥胖已成为全球性流行病，并与糖尿病、血脂异常、心血管疾病和某些类型的癌症等疾病相关。因此，了解脂肪组织的发育过程，包括脂肪生成、血管生成和细胞外基质重塑，对于揭示肥胖的病理生物学至关重要。实验小鼠模型被广泛用于深入了解这些过程，并评估新的关键参与者，特别是蛋白水解系统成分，在脂肪组织发育和肥胖中的作用。在本文中，我们将回顾现有的肥胖症体外和体内小鼠模型，并讨论它们在理解导致肥胖的机制方面的价值。
