Blanco Luis Z, Schein Caitlin O, Patel Tushar, Heagley Dawn E, Cimbaluk David J, Reddy Vijaya, Gattuso Paolo
Department of Pathology, Rush University Medical Center, Chicago, Illinois, USA.
Diagn Cytopathol. 2013 Aug;41(8):742-51. doi: 10.1002/dc.22962. Epub 2013 Feb 28.
Metanephric adenoma of the kidney is an uncommon benign epithelial neoplasm with only a small number of reports that describe its cytologic features. We describe two additional cases of metanephric adenoma diagnosed on fine-needle aspiration biopsy and review the available literature. Our cases showed similar cytology and were composed of cellular smears with numerous clusters of small, oval to round cells arranged in a microfollicular pattern and papillary configurations. The tumor cells had scant cytoplasm, fine chromatin and absent nucleoli. Psamomma bodies, nuclear atypia, cellular cpleomorphism, necrosis, and mitoses were absent. Because of the rarity of this tumor and the common cytologic features it shares with other lesions, including malignant tumors such as Wilms' tumor and papillary renal cell carcinoma, awareness of the cytologic features of metanephric adenoma may aid in avoiding a diagnosis of malignancy, especially preoperatively, and in guiding the proper management for the patients.
肾后肾腺瘤是一种罕见的良性上皮性肿瘤，仅有少数报告描述其细胞学特征。我们描述了另外两例经细针穿刺活检诊断为后肾腺瘤的病例，并回顾了现有文献。我们的病例显示出相似的细胞学特征，由细胞涂片组成，有许多小的椭圆形至圆形细胞簇，呈微滤泡状排列和乳头构型。肿瘤细胞胞质稀少，染色质细腻，无核仁。无砂粒体、核异型性、细胞多形性、坏死和有丝分裂。由于这种肿瘤罕见，且与其他病变（包括肾母细胞瘤和乳头状肾细胞癌等恶性肿瘤）具有共同的细胞学特征，认识后肾腺瘤的细胞学特征可能有助于避免误诊为恶性肿瘤，尤其是在术前，并有助于指导患者的正确治疗。
