Cho Seong J, Nam Hyoryung, An Taechang, Lim Geunbae
Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea.
J Nanosci Nanotechnol. 2012 Dec;12(12):9047-50. doi: 10.1166/jnn.2012.6758.
Controlling the architecture of electrospun fibers is one of the key issues in tissue engineering. This report describes a rapid and reproducible patterning method for the fabrication of an electrospun fibrous scaffold. The electrospun fibers were deposited on a patterned electrode. The patterned scaffold was fabricated using a thin insulating film between layers of this electrode. For a tissue engineering application, poly(lactic-co-glycolic acid) (PLGA), a biocompatible and biodegradable material, was electrospun. Fibroblast cells were cultured on the fibrous PLGA scaffold and the viability, morphology, and distribution of the cells were studied.
控制电纺纤维的结构是组织工程中的关键问题之一。本报告描述了一种用于制造电纺纤维支架的快速且可重复的图案化方法。电纺纤维沉积在图案化电极上。使用该电极层之间的薄绝缘膜制造图案化支架。对于组织工程应用，将具有生物相容性和可生物降解性的聚乳酸-乙醇酸共聚物（PLGA）进行电纺。在纤维状PLGA支架上培养成纤维细胞，并研究细胞的活力、形态和分布。
