Pollack P F, Wood J G, Solomon T
Department of Pediatrics, University of Texas Health Sciences Center, Houston 77030.
Dig Dis Sci. 1990 Jun;35(6):749-58. doi: 10.1007/BF01540179.
Secretin is present in the intestine of a number of developing species, and plasma secretin levels are elevated in newborn pigs and humans. Secretin stimulates the growth and affects the enzymatic composition of the stomach, small intestine, and pancreas in adult rats. This suggests a possible role for secretin in the rapid postnatal growth of these organs. We investigated this hypothesis by injecting rats subcutaneously with secretin (100 micrograms/kg) every 12 hr for seven days beginning on postnatal day 3, 6, 13, or 24. Growth parameters (weight, content of protein, DNA) as well as the composition of organ-specific enzymes of the stomach, small intestine, and pancreas were measured. Secretin increased growth parameters of the stomach and small intestine in a similar pattern, and in a quantitatively different fashion from that observed in the pancreas. Secretin's effects were also dependent on postnatal age for all organs studied. These data demonstrate that secretin can influence organ growth and enzyme composition of the stomach, small intestine, and pancreas of developing rats and may be one factor regulating growth and development of these organs.
促胰液素存在于许多发育中物种的肠道中，新生猪和人类的血浆促胰液素水平会升高。促胰液素能刺激成年大鼠胃、小肠和胰腺的生长并影响其酶组成。这表明促胰液素在这些器官出生后的快速生长中可能发挥作用。我们通过从出生后第3天、第6天、第13天或第24天开始，每隔12小时给大鼠皮下注射促胰液素（100微克/千克），持续7天，来研究这一假设。测量了生长参数（体重、蛋白质含量、DNA）以及胃、小肠和胰腺的器官特异性酶组成。促胰液素以类似的模式增加了胃和小肠的生长参数，且与在胰腺中观察到的情况在数量上有所不同。促胰液素的作用也取决于所研究的所有器官的出生后年龄。这些数据表明，促胰液素可影响发育中大鼠胃、小肠和胰腺的器官生长及酶组成，可能是调节这些器官生长和发育的一个因素。
