Pereira-Lopes O, Sampaio-Maia B, Sampaio S, Vieira-Marques P, Monteiro-da-Silva F, Braga A C, Felino A, Pestana M
Department of Oral Medicine and Oral Surgery, Faculty of Dental Medicine, University of Porto, Portugal.
Oral Dis. 2013 Oct;19(7):666-72. doi: 10.1111/odi.12051. Epub 2012 Dec 21.
To compare oral health status between renal transplant recipients (RTRs) receiving tacrolimus (Tac) or everolimus (ERL) as immunosuppressive therapy.
This study is a cross-sectional study.
Thirty-six RTRs receiving Tac and 22 RTRs receiving ERL were included in the study. Age, gender, time since transplant and pharmacological data were recorded for both groups. Oral health status was assessed through the evaluation of teeth, periodontal parameters as well as saliva flow rate and pH.
RTRs receiving ERL were older than those receiving Tac. No differences were found between groups concerning oral hygiene habits, oral symptoms, smoking habits, unstimulated and stimulated saliva flow rate and pH, clinical attachment level or the number of decayed, missing and filled teeth. However, RTRs receiving ERL presented lower visible plaque index and lower values for bleeding on probing when compared to RTRs receiving Tac. In addition, RTRs receiving ERL presented a gingival index varying from normal to moderate inflammation whereas RTRs receiving Tac presented a gingival index varying from mild to severe inflammation.
RTRs receiving ERL have lower periodontal inflammation when compared to RTRs receiving Tac.
比较接受他克莫司（Tac）或依维莫司（ERL）作为免疫抑制治疗的肾移植受者（RTRs）的口腔健康状况。
本研究为横断面研究。
本研究纳入了36例接受Tac治疗的RTRs和22例接受ERL治疗的RTRs。记录两组的年龄、性别、移植后的时间以及药理学数据。通过评估牙齿、牙周参数以及唾液流速和pH值来评估口腔健康状况。
接受ERL治疗的RTRs比接受Tac治疗的RTRs年龄更大。两组在口腔卫生习惯、口腔症状、吸烟习惯、非刺激性和刺激性唾液流速及pH值、临床附着水平或龋失补牙数方面均未发现差异。然而，与接受Tac治疗的RTRs相比，接受ERL治疗的RTRs的可见菌斑指数更低，探诊出血值更低。此外，接受ERL治疗的RTRs的牙龈指数在正常至中度炎症之间变化，而接受Tac治疗的RTRs的牙龈指数在轻度至重度炎症之间变化。
与接受Tac治疗的RTRs相比，接受ERL治疗的RTRs的牙周炎症更低。
