Amplification of mineralocorticoid activity of aldosterone by 18-hydroxy-corticosterone and 18-hydroxy-19-nor-corticosterone in adrenalectomized rats.
作者信息
Rosenthal T, Shani M, Peleg E, Harnik M
机构信息
Hypertension Unit, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Israel.
出版信息
Endocr Res. 1990;16(2):185-91. doi: 10.1080/07435809009032998.
PMID:2344835
Abstract
A combination of aldosterone (1 micrograms) with either 18-OH-corticosterone (1 micrograms) or 18-OH-19-norcorticosterone (1 micrograms) injected to adrenalectomized rats indicated an amplification of mineralocorticoid activity as expressed by Na/K ratio in urine. Without aldosterone their mineralocorticoid potency was negligible.
摘要
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