18-羟皮质酮和18-羟-19-去甲皮质酮对肾上腺切除大鼠醛固酮盐皮质激素活性的增强作用
Amplification of mineralocorticoid activity of aldosterone by 18-hydroxy-corticosterone and 18-hydroxy-19-nor-corticosterone in adrenalectomized rats.
作者信息
Rosenthal T, Shani M, Peleg E, Harnik M
机构信息
Hypertension Unit, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Israel.
出版信息
Endocr Res. 1990;16(2):185-91. doi: 10.1080/07435809009032998.
PMID:2344835
Abstract
A combination of aldosterone (1 micrograms) with either 18-OH-corticosterone (1 micrograms) or 18-OH-19-norcorticosterone (1 micrograms) injected to adrenalectomized rats indicated an amplification of mineralocorticoid activity as expressed by Na/K ratio in urine. Without aldosterone their mineralocorticoid potency was negligible.
摘要
将醛固酮（1微克）与18-羟皮质酮（1微克）或18-羟-19-去甲皮质酮（1微克）联合注射给肾上腺切除的大鼠，结果表明，以尿中钠/钾比值表示的盐皮质激素活性增强。没有醛固酮时，它们的盐皮质激素效力可忽略不计。
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