Conte Neto Nicolau, de Andrade Cleverton Roberto, Spolidorio Luis Carlos, Planeta Cleópatra da Silva, Cruz Fábio Cardoso, de Souza Bastos Alliny, Marcantonio Elcio
Division of Periodontology, Department of Diagnosis and Surgery, School of Dentistry, UNESP - Univ. Estadual Paulista, Araraquara, Brazil.
Clin Implant Dent Relat Res. 2014 Oct;16(5):762-71. doi: 10.1111/cid.12046. Epub 2013 Feb 28.
The purposes of this study were to evaluate the influence of chronic stress (CS) on implant osseointegration and also to analyze whether alendronate (ALN) therapy could prevent these eventual stress-negative effects.
Adult male Holtzmann rats were assigned to one of the four experimental groups: AL (ALN; 1 mg/kg/week; n = 12), ALS (ALN + CS; 1 mg/kg/week; n = 12), CTL (sterile physiological saline; n = 12), or CTLS (sterile physiological saline + CS; n = 12). After 58 days of drug therapy, the ALS and CTLS groups were exposed to CS, and 2 days later all animals underwent tibial implant installation. The animals were euthanized 28 days following the operative surgical procedure.
It was observed that the CTLS group presented an impairment of bone metabolism represented by lowest levels of bone-specific alkaline phosphatase and bone area fraction occupancy values. Furthermore, these animals presented a higher proportion of empty osteocytic lacunae. In contrast, the ALN therapy showed increased osseointegration and torque value parameters, regardless of stress exposition.
Analysis of the data presented suggests that CS partially impairs the osseointegration of tibial implants and that ALN therapy is able to prevent these negative effects.
本研究旨在评估慢性应激（CS）对种植体骨整合的影响，并分析阿仑膦酸盐（ALN）治疗是否能够预防这些最终的应激负面影响。
成年雄性霍尔茨曼大鼠被分为四个实验组之一：AL（ALN；1毫克/千克/周；n = 12）、ALS（ALN + CS；1毫克/千克/周；n = 12）、CTL（无菌生理盐水；n = 12）或CTLS（无菌生理盐水 + CS；n = 12）。药物治疗58天后，ALS组和CTLS组暴露于CS，2天后所有动物接受胫骨种植体植入。手术操作28天后对动物实施安乐死。
观察到CTLS组出现骨代谢受损，表现为骨特异性碱性磷酸酶水平和骨面积分数占有率值最低。此外，这些动物的空骨陷窝比例更高。相比之下，无论是否暴露于应激，ALN治疗均显示骨整合和扭矩值参数增加。
对所呈现数据的分析表明，CS会部分损害胫骨种植体的骨整合，而ALN治疗能够预防这些负面影响。
