Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
J Infect Dis. 2013 Jun 1;207(11):1675-83. doi: 10.1093/infdis/jit081. Epub 2013 Feb 28.
Human ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by MBL2) bind to specific pathogen-associated molecular patterns, activate the complement lectin cascade in a similar manner, and are associated with several infectious diseases. Our recently published study established certain FCN2 promoter variants and ficolin-2 serum levels as protective factors against schistosomiasis.
We used the Nigerian cohort from our recently published study, which included 163 Schistosoma haematobium-infected individuals and 183 matched healthy subjects, and investigated whether MBL deficiency and MBL2 polymorphisms are associated with schistosomiasis.
MBL serum levels were significantly higher in controls and were associated with protection (P < .0001). The -550H minor allele was significantly associated with protection (P = .03), and the heterozygous genotypes -550HL were observed to confer protection (P = .03). The MBL2*HYPA haplotype was significantly associated with protection (P = .03), with significantly higher serum MBL levels in controls (P = .00073). The heterozygous 6-bp deletion in the promoter was observed to be a susceptibility factor in schistosomiasis (P = .03).
In agreement with findings from our recently published study, the findings reported here support the observation that MBL is also associated with protection in schistosomiasis.
人纤维胶凝蛋白 2（由 FCN2 编码）和甘露聚糖结合凝集素（由 MBL2 编码）与特定的病原体相关分子模式结合，以相似的方式激活补体凝集素级联反应，并与多种传染病相关。我们最近发表的研究确定了某些 FCN2 启动子变体和纤维胶凝蛋白-2 血清水平是对抗血吸虫病的保护因素。
我们使用了我们最近发表的研究中的尼日利亚队列，其中包括 163 名埃及血吸虫感染者和 183 名匹配的健康对照者，并研究了甘露聚糖结合蛋白缺乏和 MBL2 多态性是否与血吸虫病有关。
对照组的 MBL 血清水平显著升高，并与保护作用相关（P<0.0001）。-550H 次要等位基因与保护作用显著相关（P=0.03），杂合基因型-550HL 被观察到具有保护作用（P=0.03）。MBL2*HYPA 单倍型与保护作用显著相关（P=0.03），对照组的 MBL 血清水平显著升高（P=0.00073）。启动子中的 6 个碱基对缺失杂合子被观察到是血吸虫病的易感因素（P=0.03）。
与我们最近发表的研究结果一致，这里报告的研究结果支持了 MBL 也与血吸虫病的保护作用相关的观察。
