Ogawa Masaki, Akahira Saeko, Takahashi Satoshi, Shimoda Yuki, Sato Megumi, Sato Akira, Terada Yukihiro
Perinatal Care Center, Department of Obstetrics and Gynecology, Akita University Hospital, Hondo, Akita, Japan.
Blood Coagul Fibrinolysis. 2013 Apr;24(3):344-6. doi: 10.1097/MBC.0b013e32835975b1.
Recombinant activated factor VII has been used to effectively treat uncontrolled massive hemorrhage at parturition in an off-label manner. Interventional radiology, including vessel embolization of the internal iliac artery or uterine artery for postpartum hemorrhage, is now familiar to obstetricians. However, this therapeutic technique is applicable only in patients who are hemodynamically stable. We encountered a case with severe and uncontrolled postpartum bleeding from the vaginal fornix. The patient received a low dose (<20 μg/kg) of factor VIIa and subsequently underwent vessel embolization. We herein report that this stepwise treatment was very effective for uncontrolled bleeding.
重组活化因子VII已被用于以超适应症方式有效治疗分娩时无法控制的大量出血。介入放射学，包括髂内动脉或子宫动脉血管栓塞术治疗产后出血，现在产科医生已熟知。然而，这种治疗技术仅适用于血流动力学稳定的患者。我们遇到一例阴道穹窿严重且无法控制的产后出血病例。该患者接受了低剂量（<20μg/kg）的VIIa因子治疗，随后进行了血管栓塞术。我们在此报告，这种分步治疗对无法控制的出血非常有效。
