Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.
J Perinatol. 2013 Aug;33(8):619-21. doi: 10.1038/jp.2013.20. Epub 2013 Feb 28.
To determine the effects of low-dose dopamine on urine output (UOP) in very low birth weight premature neonates.
Retrospective cohort study of all low-dose (3-5 μg kg(-1) per min) dopamine infusions >24-h duration in neonates 1500 g and 32 weeks gestation from August 2009 through September 2011. Linear regression was used to estimate the impact of covariates on UOP.
We identified 91 episodes of low-dose dopamine use in 65 neonates. Increased UOP occurred in 64% of episodes. Low-dose dopamine use was associated with a 0.6 ml kg(-1) h(-1) increase in UOP (P<0.001) and a 1.3 ml kg(-1)h(-1) increase when baseline UOP was <1.5 ml kg(-1) h(-1) (P<0.001). The improvement remained statistically significant after controlling for medications (diuretics and hydrocortisone) and fluid intake.
Low-dose dopamine use was associated with increased UOP in very low birth weight neonates.
确定小剂量多巴胺对极低出生体重早产儿尿量（UOP）的影响。
对 2009 年 8 月至 2011 年 9 月期间胎龄 ＜32 周、体重＜1500g 的所有接受小剂量（3-5μg/kg/min）多巴胺输注＞24 小时的早产儿进行回顾性队列研究。采用线性回归估计协变量对 UOP 的影响。
我们确定了 65 例早产儿中 91 例小剂量多巴胺的使用情况。64%的病例出现 UOP 增加。小剂量多巴胺的使用与 UOP 增加 0.6ml/kg/h（P＜0.001）相关，当基础 UOP＜1.5ml/kg/h 时，UOP 增加 1.3ml/kg/h（P＜0.001）。在控制药物（利尿剂和氢可的松）和液体摄入后，这种改善仍然具有统计学意义。
小剂量多巴胺的使用与极低出生体重儿 UOP 的增加有关。
