[水貂免疫球蛋白同种异型与阿留申病]

[Mink IgG-allotypes and Aleutian disease].

作者信息

Fomicheva I I, Popova N A, Tservadze D K, Volkova O Iu, Kochlashvili T I, Baranov O K

出版信息

Genetika. 1990 Jan;26(1):109-13.

Abstract

IgG polymorphism (allotypes H3, H4, H6 and H8 of constant region of the gamma-chain) was investigated in healthy and affected with Aleutian disease (AD) minks from two Siberian and one Danish populations. In all three populations, the expression of H3 and H4 allotypes was strongly associated with AD. Among the AD minks the frequency of H6, H8 phenotype was found to be decreased, whereas the frequency of H3, H4, H6, H8 phenotype was significantly increased. At the same time, the populational distribution of the rest phenotypes was similar among healthy and AD minks. The H3, H4, H6, H8 minks showed the highest pathomorphological characteristics of AD. Based on the data concerning mink H3 and H4, and human Gm allotypes, their role as possible genetic markers for hereditary susceptibility to distinct disease is discussed.

摘要

对来自两个西伯利亚种群和一个丹麦种群的健康水貂以及感染阿留申病（AD）的水貂进行了IgG多态性（γ链恒定区的H3、H4、H6和H8同种异型）研究。在所有这三个种群中，H3和H4同种异型的表达与阿留申病密切相关。在感染阿留申病的水貂中，发现H6、H8表型的频率降低，而H3、H4、H6、H8表型的频率显著增加。同时，其余表型在健康水貂和感染阿留申病的水貂中的群体分布相似。具有H3、H4、H6、H8表型的水貂表现出阿留申病最高的病理形态学特征。基于有关水貂H3和H4以及人类Gm同种异型的数据，讨论了它们作为不同疾病遗传易感性的可能遗传标记的作用。

相似文献

1

[Mink IgG-allotypes and Aleutian disease].[水貂免疫球蛋白同种异型与阿留申病]

Genetika. 1990 Jan;26(1):109-13.

2

[Immunoglobulin (IgG) allotypes of the American mink with Aleutian disease].[患有阿留申病的美国水貂的免疫球蛋白（IgG）同种异型]

Genetika. 1987 Jul;23(7):1339-41.

3

Genetic polymorphism of IgG in the mink. 7. Expression of the C gamma-allotypes in domestic mink infected with the Aleutian disease virus.水貂IgG的遗传多态性。7. 感染阿留申病病毒的家养水貂中Cγ-同种异型的表达。

Exp Clin Immunogenet. 1991;8(2):107-14.

4

[Activation of expression of two immunoglobulin SN-genes in the American mink with Aleutian disease].[阿留申病对美国水貂两个免疫球蛋白SN基因表达的激活作用]

Genetika. 1991 May;27(5):895-902.

5

Genetic polymorphism of IgG in the mink. VIII. A quantitative study of the expression of C gamma-allotypes (H3, H4, H6, H8) in sera.水貂IgG的遗传多态性。VIII. 血清中Cγ-同种异型（H3、H4、H6、H8）表达的定量研究。

Exp Clin Immunogenet. 1992;9(1):24-32.

6

Genetic polymorphism of IgG in mink. II. A genetic analysis of allotypes.水貂IgG的遗传多态性。II. 同种异型的遗传分析。

Exp Clin Immunogenet. 1986;3(2):65-74.

7

[Study of the Lpm-system of mink allotypes in relation to Aleutian mink disease].

Genetika. 1985 Nov;21(11):1896-903.

8

Genetic polymorphism of IgG in mink. I. Identification of 8 allotypes.水貂IgG的遗传多态性。I. 8种同种异型的鉴定。

Exp Clin Immunogenet. 1986;3(1):10-9.

9

Genetic polymorphism of IgG in the mink. III. Instability of expression and the problem of the genetic control of C gamma-allotypes.水貂IgG的遗传多态性。III. 表达的不稳定性及Cγ-同种异型的遗传控制问题。

Exp Clin Immunogenet. 1987;4(2):73-80.

10

Genetic polymorphism of IgG in the mink. IX. High proportion of allotype-producing lymphocytes in individuals with minor level of allotypes H3 and H4 in serum.水貂IgG的遗传多态性。IX。血清中同种异型H3和H4水平较低的个体中产生同种异型淋巴细胞的比例较高。

Exp Clin Immunogenet. 1992;9(3):141-8.

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