Fomicheva I I, Popova N A, Tservadze D K, Volkova O Iu, Kochlashvili T I, Baranov O K
Genetika. 1990 Jan;26(1):109-13.
IgG polymorphism (allotypes H3, H4, H6 and H8 of constant region of the gamma-chain) was investigated in healthy and affected with Aleutian disease (AD) minks from two Siberian and one Danish populations. In all three populations, the expression of H3 and H4 allotypes was strongly associated with AD. Among the AD minks the frequency of H6, H8 phenotype was found to be decreased, whereas the frequency of H3, H4, H6, H8 phenotype was significantly increased. At the same time, the populational distribution of the rest phenotypes was similar among healthy and AD minks. The H3, H4, H6, H8 minks showed the highest pathomorphological characteristics of AD. Based on the data concerning mink H3 and H4, and human Gm allotypes, their role as possible genetic markers for hereditary susceptibility to distinct disease is discussed.
对来自两个西伯利亚种群和一个丹麦种群的健康水貂以及感染阿留申病（AD）的水貂进行了IgG多态性（γ链恒定区的H3、H4、H6和H8同种异型）研究。在所有这三个种群中，H3和H4同种异型的表达与阿留申病密切相关。在感染阿留申病的水貂中，发现H6、H8表型的频率降低，而H3、H4、H6、H8表型的频率显著增加。同时，其余表型在健康水貂和感染阿留申病的水貂中的群体分布相似。具有H3、H4、H6、H8表型的水貂表现出阿留申病最高的病理形态学特征。基于有关水貂H3和H4以及人类Gm同种异型的数据，讨论了它们作为不同疾病遗传易感性的可能遗传标记的作用。
