初发2型糖尿病青年患者生活方式单一疗法的成功案例。
Success with lifestyle monotherapy in youth with new-onset type 2 diabetes.
作者信息
Wittmeier Kristy Dm, Wicklow Brandy A, Sellers Elizabeth Ac, Griffith Angella Tr, Dean Heather J, McGavock Jonathan M
机构信息
Manitoba Institute of Child Health, John Buhler Research Centre; ; Department of Physiology, University of Manitoba, Health Sciences Centre, Winnipeg, Manitoba.
出版信息
Paediatr Child Health. 2012 Mar;17(3):129-32. doi: 10.1093/pch/17.3.129.
BACKGROUND
Evidence is lacking to support the efficacy of lifestyle modification as first-line therapy in the clinical management of type 2 diabetes mellitus (T2DM) in adolescents.
METHODS
A retrospective chart review of youth diagnosed with T2DM between 1999 and 2008 was conducted. The authors describe the percentage of youth presenting with glycosylated hemoglobin (HbA1c) of <9% who achieved/maintained target glycemic control (HbA1c ≤7.0%) with lifestyle monotherapy during the year following diagnosis.
RESULTS
Among the 275 youth with T2DM, 38% (n=104) presented with an HbA1c <9% and were prescribed lifestyle monotherapy at diagnosis. Of the 80 youth who had sufficient follow-up data over 12 months, 54% successfully maintained target glycemic control solely with lifestyle management. The mean HbA1c score at diagnosis was lower in youth who where successful on lifestlye monotherapy compared with those who were not successful.
CONCLUSIONS
A significant proportion of youth newly diagnosed with T2DM presenting with an HbA1c <9% effectively achieved/maintained target glycemic control with lifestyle recommendations alone for 12 months.
BACKGROUND
Evidence is lacking to support the efficacy of lifestyle modification as first-line therapy in the clinical management of type 2 diabetes mellitus (T2DM) in adolescents.
METHODS
A retrospective chart review of youth diagnosed with T2DM between 1999 and 2008 was conducted. The authors describe the percentage of youth presenting with glycosylated hemoglobin (HbA) of <9% who achieved/maintained target glycemic control (HbA ≤7.0%) with lifestyle monotherapy during the year following diagnosis.
RESULTS
Among the 275 youth with T2DM, 38% (n=104) presented with an HbA <9% and were prescribed lifestyle monotherapy at diagnosis. Of the 80 youth who had sufficient follow-up data over 12 months, 54% successfully maintained target glycemic control solely with lifestyle management. The mean HbA score at diagnosis was lower in youth who where successful on lifestlye monotherapy compared with those who were not successful.
CONCLUSIONS
A significant proportion of youth newly diagnosed with T2DM presenting with an HbA <9% effectively achieved/maintained target glycemic control with lifestyle recommendations alone for 12 months.
背景
缺乏证据支持生活方式改变作为青少年2型糖尿病（T2DM）临床管理一线治疗方法的疗效。
方法
对1999年至2008年间确诊为T2DM的青少年进行回顾性病历审查。作者描述了糖化血红蛋白（HbA1c）<9%的青少年在诊断后一年内通过生活方式单一疗法实现/维持目标血糖控制（HbA1c≤7.0%）的百分比。
结果
在275例T2DM青少年中，38%（n = 104）的糖化血红蛋白<9%，并在诊断时接受了生活方式单一疗法。在80例有足够12个月随访数据的青少年中，54%仅通过生活方式管理成功维持了目标血糖控制。与未成功的青少年相比，生活方式单一疗法成功的青少年诊断时的平均糖化血红蛋白评分更低。
结论
相当一部分新诊断为T2DM且糖化血红蛋白<9%的青少年仅通过生活方式建议就有效实现/维持了12个月的目标血糖控制。
背景
缺乏证据支持生活方式改变作为青少年2型糖尿病（T2DM）临床管理一线治疗方法的疗效。
方法
对1999年至2008年间确诊为T2DM的青少年进行回顾性病历审查。作者描述了糖化血红蛋白（HbA）<9%的青少年在诊断后一年内通过生活方式单一疗法实现/维持目标血糖控制（HbA≤7.0%）的百分比。
结果
在275例T2DM青少年中，38%（n = 104）的糖化血红蛋白<9%，并在诊断时接受了生活方式单一疗法。在进行了12个月充分随访的青少年中，54%仅通过生活方式管理成功维持了目标血糖控制。与未成功的青少年相比，生活方式单一疗法成功的青少年诊断时的平均糖化血红蛋白评分更低。
结论
相当一部分新诊断为T2DM且糖化血红蛋白<9%的青少年仅通过生活方式建议就有效实现/维持了12个月的目标血糖控制。
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