蝎蜇伤中毒后心肌炎中的N末端脑钠肽前体
NT-proBNP in Myocarditis after a Scorpion Sting Envenomation.
作者信息
Sagarad Suresh V, Thakur Balaram Singh, Reddy S S, K Balasubramanya, Joshi R M, Kerure Sudha Biradar
机构信息
Assistant Professor, Department of Medicine, NMC&H, Chief of Cardiology, RGSSH & SHRC , Raichur, India .
出版信息
J Clin Diagn Res. 2013 Jan;7(1):118-21. doi: 10.7860/JCDR/2012/4858.2684. Epub 2013 Jan 1.
OBJECTIVE
This study was to evaluate the levels of NT-proBNP in patients with myocarditis which occurred after a scorpion sting envenomation.
MATERIAL AND METHODS
A total of 30 patients with scorpion sting envenomation and 21 patients with heart failure which was caused by cardiomyopathy, were prospectively studied. The data included the patient demographics, clinical features, echocardiography and the NT-proBNP levels.
RESULTS
An echocardiographic evidence of myocarditis with a left ventricular ejection fraction of less than 50%, was found in 22 patients. In all the 22 patients, NT-proBNP was significantly elevated. The NT-proBNP levels were very high in the patients with severe LV dysfunction. However, it was in the normal range in the patients without an evidence of myocarditis. The elevated NT-proBNP levels were correlated with the LV dysfunction and myocarditis. When they were compared with the patients with heart failure which was caused by cardiomyopathy, the NTproBNP levels were found to be significantly more elevated in scorpion sting myocarditis.
CONCLUSIONS
The NT-proBNP levels were significantly elevated in myocarditis which occurred after a scorpion sting envenomation.
目的
本研究旨在评估蝎蜇伤中毒后发生心肌炎患者的N末端B型利钠肽原（NT-proBNP）水平。
材料与方法
前瞻性研究了30例蝎蜇伤中毒患者和21例由心肌病引起心力衰竭的患者。数据包括患者人口统计学资料、临床特征、超声心动图及NT-proBNP水平。
结果
22例患者出现心肌炎的超声心动图证据，左心室射血分数小于50%。所有22例患者的NT-proBNP均显著升高。左心室功能严重障碍患者的NT-proBNP水平非常高。然而，无心肌炎证据的患者其NT-proBNP水平在正常范围内。NT-proBNP水平升高与左心室功能障碍及心肌炎相关。与心肌病所致心力衰竭患者相比，蝎蜇伤后心肌炎患者的NT-proBNP水平显著更高。
结论
蝎蜇伤中毒后发生的心肌炎患者NT-proBNP水平显著升高。
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