Sahinarslan Asife, Boyaci Bulent, Kocaman Sinan Altan, Topal Salih, Ercin Ugur, Okyay Kaan, Bukan Neslihan, Yalçin Ridvan, Cengel Atiye
Department of Cardiology, School of Medicine, Gazi University, Ankara, Turkey.
Int J Angiol. 2012 Mar;21(1):29-34. doi: 10.1055/s-0032-1306418.
Fas/Fas ligand system contributes to the programmed cell death induced by myocardial ischemia. We investigated whether serum soluble Fas ligand (sFasL) level is independently related with the severity and extent of angiographically assessed coronary artery disease (CAD). We included 169 patients in this study. Two groups were formed based on the existence of a lesion on coronary angiography. First group included patients with normal coronary arteries (NCA; n = 53). Patients with atherosclerotic lesions were included in the second group (n = 116). We used the coronary vessel score (the number of the coronary arteries with a lesion leading to ≥ 50% luminal obstruction) and the Azar score to determine the extent and the severity of CAD. Standard enzyme-linked immunosorbent assay kits were used to measure serum sFasL levels. The serum sFasL level was higher in patients with CAD than in patients with NCA (0.52 ± 0.23 mU/mL vs. 0.45 ± 0.18 mU/mL, p = 0.023). The sFasL level correlated with Azar score (r = 0.231, p = 0.003) and with coronary vessel score (r = 0.269, p < 0.001). In the multivariate analysis, we found that age (beta: 0.188, p = 0.008), gender (beta: 0.317, p < 0.001), diabetes mellitus (DM; beta: 0.195, p = 0.008), and sFasL level (beta: 0.209, p = 0.003) were independently related with Azar score. When we used coronary vessel score as the dependent variable, we found that age (p = 0.020), gender (p < 0.001), DM (p = 0.006), and sFasL level (p = 0.001) were independent predictors. Serum sFasL level is associated with angiographically more severe CAD. Our findings suggest that sFasL level may be a biochemical surrogate of severe coronary atherosclerosis.
Fas/Fas配体系统参与心肌缺血诱导的程序性细胞死亡。我们研究了血清可溶性Fas配体（sFasL）水平是否与血管造影评估的冠状动脉疾病（CAD）的严重程度和范围独立相关。本研究纳入了169例患者。根据冠状动脉造影是否存在病变分为两组。第一组包括冠状动脉正常的患者（NCA；n = 53）。第二组包括有动脉粥样硬化病变的患者（n = 116）。我们使用冠状动脉血管评分（导致管腔阻塞≥50%的病变冠状动脉数量）和阿扎尔评分来确定CAD的范围和严重程度。使用标准酶联免疫吸附测定试剂盒测量血清sFasL水平。CAD患者的血清sFasL水平高于NCA患者（0.52±0.23 mU/mL对0.45±0.18 mU/mL，p = 0.023）。sFasL水平与阿扎尔评分（r = 0.231，p = 0.003）和冠状动脉血管评分（r = 0.269，p < 0.001）相关。在多变量分析中，我们发现年龄（β：0.188，p = 0.008）、性别（β：0.317，p < 0.001）、糖尿病（DM；β：0.195，p = 0.008）和sFasL水平（β：0.209，p = 0.003）与阿扎尔评分独立相关。当我们将冠状动脉血管评分作为因变量时，我们发现年龄（p = 0.020）、性别（p < 0.001）、DM（p = 0.006）和sFasL水平（p = 0.001）是独立预测因素。血清sFasL水平与血管造影显示的更严重CAD相关。我们的研究结果表明，sFasL水平可能是严重冠状动脉粥样硬化的生化替代指标。
