合成双水杨酸铋：乙酰水杨酸铋的合成、结构和对幽门螺杆菌的活性。
Making bispirin: synthesis, structure and activity against Helicobacter pylori of bismuth(III) acetylsalicylate.
机构信息
School of Chemistry, Monash University, Clayton, Melbourne, VIC 3800, Australia.
出版信息
Chem Commun (Camb). 2013 Apr 11;49(28):2870-2. doi: 10.1039/c3cc40645h.
PMID:23450139
Abstract
Reaction of Bi(O(t)Bu)3 with aspirin (acetylsalicylic acid = aspH) in dry toluene results in the bismuth(III) complex, [Bi(O2C(C6H4)OAc)3]∞ 1 (O2C(C6H4)OAc = asp), minimum inhibitory concentration (MIC) against Helicobacter pylori ≥ 6.25 μg mL(-1), while the inclusion of a stoichiometric equivalent of KO(t)Bu leads to crystals of the bismuthate salt [KBi(O2C(C6H4)OAc)4]∞ 2.
摘要
Bi(O(t)Bu)3 与阿司匹林（乙酰水杨酸 = aspH）在干燥的甲苯中反应生成三（乙酰氧基）合铋(III) ∞ 1 [Bi(O2C(C6H4)OAc)3]，对幽门螺杆菌的最小抑菌浓度（MIC）≥6.25μg mL(-1)，而加入等摩尔的 KO(t)Bu 则得到铋酸盐 [KBi(O2C(C6H4)OAc)4]∞ 2 的晶体。
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