Keogan Donal M, Griffith Darren M
Centre for Synthesis & Chemical Biology, Department of Pharmaceutical & Medicinal Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 2, Ireland.
Molecules. 2014 Sep 23;19(9):15258-97. doi: 10.3390/molecules190915258.
: Bismuth compounds have been used extensively as medicines and in particular for the treatment of gastrointestinal ailments. In addition to bismuth's well known gastroprotective effects and efficacy in treating H. pylori infection it also has broad anti-microbial, anti-leishmanial and anti-cancer properties. Aspects of the biological chemistry of bismuth are discussed and biomolecular targets associated with bismuth treatment are highlighted. This review strives to provide the reader with an up to date account of bismuth-based drugs currently used to treat patients and discuss potential medicinal applications of bismuth drugs with reference to recent developments in the literature. Ultimately this review aims to encourage original contributions to this exciting and important field.
铋化合物已被广泛用作药物，尤其用于治疗胃肠道疾病。除了铋众所周知的胃保护作用以及治疗幽门螺杆菌感染的功效外，它还具有广泛的抗菌、抗利什曼原虫和抗癌特性。本文讨论了铋的生物化学方面，并突出了与铋治疗相关的生物分子靶点。这篇综述力求为读者提供目前用于治疗患者的铋基药物的最新情况，并参照文献中的最新进展讨论铋药物的潜在医学应用。最终，这篇综述旨在鼓励对这一令人兴奋且重要的领域做出原创贡献。
