Xuan Xiao-yu, Wang Ya-jing, Tian Hui, Pi Jia-xin, Sun Shi-zhen, Zhang Wei-ling
Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China.
Zhong Yao Cai. 2012 Sep;35(9):1508-11.
To study formulation of self-microemulsifying drug delivery system (SMEDDS) of mangiferin phospholipid complex and improve dissolution and bioavailability of mangiferin.
Ternary phase diagram was applied to optimize the prescription of self-microemulsifying drug delivery system of mangiferin phospholipid complex, and the best recipe was selected by comprehensive evaluation of the speed of microemulsifying, microemulsion size and electric potential.
The optimum formulation of SMEDDS was composed of IPM-Cremphor EL35-labrasol = 2 : 4.8 : 3.2.
Self-microemulsifying drug delivery system of mangiferin phospholipid complex can effectively improve the dissolution of Mangiferin.
研究芒果苷磷脂复合物自微乳化给药系统（SMEDDS）的处方，提高芒果苷的溶出度和生物利用度。
应用三元相图优化芒果苷磷脂复合物自微乳化给药系统的处方，并通过对微乳化速度、微乳液粒径和电位的综合评价筛选出最佳处方。
SMEDDS的最佳处方为IPM-聚氧乙烯蓖麻油EL35-月桂酰基聚氧乙烯甘油酯=2:4.8:3.2。
芒果苷磷脂复合物自微乳化给药系统可有效提高芒果苷的溶出度。
