Division of Hematology-Oncology, Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310003, PR China.
Leuk Res. 2013 Jun;37(6):671-4. doi: 10.1016/j.leukres.2013.02.002. Epub 2013 Feb 28.
The prognostic value of absolute lymphocyte count (ALC) has been a recent matter of debate in childhood acute lymphoblastic leukemia (ALL). In the current study, ALCs at the time of diagnosis (ALC-0), after 7 days of initial therapy (ALC-8) and at interim of the induction therapy (ALC-22) were examined in Chinese children with B-cell precursor (BCP) ALL and correlated with the level of minimal residual disease (MRD) at day 22 of induction therapy. Medical and laboratory records of 140 patients diagnosed with childhood BCP ALL were retrieved and analyzed. ALC-22 is significantly correlated with MRD level at day 22 of therapy and can be a good prognostic factor for childhood BCP-ALL. Furthermore, lymphocyte count at initial diagnosis is correlated with MRD level at day 22 in childhood BCP-ALL with the immnunophenotype of CD19(pos)/CD10(pos)/CD34(pos)/CD45(neg) and role as a new prognostic factor was determined.
绝对淋巴细胞计数（ALC）在儿童急性淋巴细胞白血病（ALL）中的预后价值一直是最近争论的焦点。本研究对中国 B 细胞前体（BCP）ALL 患儿进行了诊断时（ALC-0）、初始治疗后 7 天（ALC-8）和诱导治疗中期（ALC-22）的 ALC 检测，并与诱导治疗第 22 天的微小残留病（MRD）水平相关联。回顾性分析了 140 例诊断为儿童 BCP ALL 的患者的医疗和实验室记录。ALC-22 与治疗第 22 天的 MRD 水平显著相关，是儿童 BCP-ALL 的一个良好预后因素。此外，免疫表型为 CD19(pos)/CD10(pos)/CD34(pos)/CD45(neg)的儿童 BCP-ALL 中，初诊时的淋巴细胞计数与第 22 天的 MRD 水平相关，可作为新的预后因素。
