Gastroenterology Unit, Brotzu Hospital, Cagliari, Italy.
J Crohns Colitis. 2013 Nov;7(10):769-79. doi: 10.1016/j.crohns.2013.01.009. Epub 2013 Mar 1.
The clinical introduction of tumour necrosis factor (TNF) inhibitors has deeply changed the treatment of inflammatory bowel diseases (IBD). It has demonstrated impressive efficacy as compared to alternative treatments, allowing for the chance to achieve near-remission and long-term improvement in function and quality of life and to alter the natural history of Crohn's disease (CD) and ulcerative colitis (UC). As a consequence of longer follow-up periods the number of side effects which may be attributed to treatment with biologics is growing significantly. Cutaneous reactions are among the most common adverse reactions. These complications include injection site reactions, cutaneous infections, immune-mediated complications such as psoriasis and lupus-like syndrome and rarely skin cancers. We review the recent literature and draw attention to dermatological side effects of anti-TNF therapy of inflammatory bowel disease.
肿瘤坏死因子（TNF）抑制剂的临床应用深刻地改变了炎症性肠病（IBD）的治疗方式。与其他治疗方法相比，TNF 抑制剂疗效显著，使患者有机会达到近乎缓解，并长期改善功能和生活质量，改变克罗恩病（CD）和溃疡性结肠炎（UC）的自然病程。随着随访时间的延长，可能与生物制剂治疗相关的副作用数量显著增加。皮肤反应是最常见的不良反应之一。这些并发症包括注射部位反应、皮肤感染、免疫介导的并发症，如银屑病和狼疮样综合征，以及罕见的皮肤癌。我们回顾了最近的文献，并提请注意抗 TNF 治疗炎症性肠病的皮肤副作用。
