Department of Psychobiology and Mind, Brain and Behavior Research Center (CIMCYC), University of Granada, Granada 18071, Spain.
Brain Res Bull. 2013 May;94:40-8. doi: 10.1016/j.brainresbull.2013.02.003. Epub 2013 Feb 21.
This study analyzed the effects of systemic oxytocin (OT) administration and 48-h food deprivation on the polydipsia, hyperphagia, and polyuria produced by electrolytic lesions of the mediobasal hypothalamus (MBH). In a first experiment, food deprivation transiently decreased the polydipsic response, whereas food deprivation plus OT administration reduced the water intake and urine excretion of polydipsic animals but not their subsequent food intake. These results were replicated in a second experiment (20 days), which also showed that OT potentiates sodium excretion, reducing the estimated plasma sodium levels in food-deprived MBH-lesioned animals. Administration of OT on day 21 to food-deprived (from day 20 to 22) animals (second period of the experiment 2) blocked the differences in water intake and urine excretion volumes between MBH and control animals on days 21 and 22. Subsequently, this 48-h food deprivation induced an additional and lasting (days 23-40) reduction in the intake of water and food of MBH animals. According to these findings, OT administration and/or food deprivation may potentially exert enduring reducing effects on the polydipsia, polyuria, and hyperphagia of MBH syndrome.
这项研究分析了全身给予催产素（OT）和 48 小时禁食对中脑基底部（MBH）电解损伤引起的多饮、多食和多尿的影响。在第一个实验中，禁食短暂地降低了多饮反应，而禁食加 OT 给药减少了多饮动物的水摄入量和尿量，但不影响它们随后的食物摄入量。第二个实验（20 天）复制了这些结果，该实验还表明 OT 增强了钠排泄，降低了禁食 MBH 损伤动物的估计血浆钠水平。在禁食（第 20 天至 22 天）动物（实验 2 的第二期）中于第 21 天给予 OT 给药阻断了 MBH 和对照动物在第 21 天和第 22 天在水摄入量和尿量方面的差异。随后，这 48 小时禁食导致 MBH 动物的水和食物摄入进一步减少且持续（第 23-40 天）。根据这些发现，OT 给药和/或禁食可能对 MBH 综合征的多饮、多尿和多食产生持久的减少作用。
