Domingo J L, Ortega A, Bosque M A, Corbella J
Laboratory of Toxicology and Biochemistry, School of Medicine, Sant Llorenç, Reus, Spain.
Life Sci. 1990;46(18):1287-92. doi: 10.1016/0024-3205(90)90361-t.
The sodium salt of 2,3-dimercaptopropane-1-sulfonic acid (DMPS), a water soluble metal complexing agent, was administered to four groups of pregnant Swiss mice at 0, 70, 210, and 630 mg/kg/day by two dosing schedules: gestation day 14 until birth (prenatal exposure), and gestation day 14 until postnatal day 21 (pre- and postnatal section). Dams were allowed to deliver and the number of live and dead pups recorded. Each pup was sexed and weighed on days 0, 4, 14, and 21. Also, pinna detachment, incisor eruption and eye opening were monitored. No adverse effects on offspring survival or development were evident in either exposures at doses employed in this study. The "no observable effect level" (NOEL) for health hazard to the developing fetus or pup was 630 mg DMPS/kg/day. This dose is much higher than the amounts of DMPS usually administered in human heavy metal poisoning.
2,3 - 二巯基丙烷 - 1 - 磺酸（DMPS）的钠盐是一种水溶性金属络合剂，通过两种给药方案，以0、70、210和630毫克/千克/天的剂量给予四组怀孕的瑞士小鼠：妊娠第14天至出生（产前暴露），以及妊娠第14天至出生后第21天（产前和产后阶段）。让母鼠分娩并记录存活和死亡幼崽的数量。在第0、4、14和21天对每只幼崽进行性别鉴定和称重。此外，监测耳廓分离、门齿萌出和睁眼情况。在本研究使用的剂量下，两种暴露对后代的存活或发育均未显示出明显的不良影响。对发育中的胎儿或幼崽健康危害的“未观察到有害作用水平”（NOEL）为630毫克DMPS/千克/天。该剂量远高于人类重金属中毒时通常使用的DMPS量。
