David Geffen School of Medicine at UCLA, UCLA Center for Clinical AIDS Research and Education (CARE Center), University of California, Los Angeles, CA 90035, USA.
Curr Opin HIV AIDS. 2013 May;8(3):224-9. doi: 10.1097/COH.0b013e32835ef0a1.
Interest in finding a potential 'cure' for HIV has taken on greater interest and urgency since the report of an individual who underwent allogeneic stem cell transplant from a CCR5 delta 32 homozygote donor after high-dose chemotherapy for acute myeloid leukemia. The potential role of cancer chemotherapy and other cancer-directed treatment approaches is discussed in the context of their potential role in helping to eliminate HIV from the infected host.
Cancer chemotherapy and other cancer-targeted agents have been used successfully in treating a variety of malignancies in both HIV-infected and HIV-uninfected individuals. Lessons learned from these strategies may be of importance in helping to define more effective ways of controlling and eliminating HIV as well. Application of these anticancer strategies to patients with HIV are beginning to be explored and may help determine their potential usefulness in this disease as well.
Although cytotoxic chemotherapy is a crude and not particularly effective way of removing HIV latently infected cells and tissue reservoirs, several new approaches to targeting and controlling cancer proliferation may be of value in HIV cure research and may one day help to end this disease.
自从报道一位急性髓细胞白血病患者在接受高剂量化疗后，接受了 CCR5 Δ32 纯合子供体的同种异体干细胞移植，从而治愈 HIV 后，人们对寻找 HIV 潜在“治愈方法”的兴趣变得更加浓厚，也更加紧迫。本文将讨论癌症化疗和其他针对癌症的治疗方法在帮助受感染宿主清除 HIV 方面的潜在作用。
癌症化疗和其他针对癌症的药物已成功用于治疗 HIV 感染者和 HIV 阴性者的多种恶性肿瘤。从这些策略中吸取的经验教训对于帮助确定更有效的控制和消除 HIV 的方法可能也很重要。开始探索将这些抗癌策略应用于 HIV 患者，这可能有助于确定它们在该疾病中的潜在用途。
虽然细胞毒性化疗是一种清除潜伏感染 HIV 的细胞和组织储库的原始且效果并不特别理想的方法，但针对控制癌症增殖的几种新方法可能对 HIV 治愈研究有价值，并可能有朝一日有助于终结这种疾病。
