Department of Psychology, University of Konstanz, Konstanz, Germany.
J Alzheimers Dis. 2013;35(3):575-87. doi: 10.3233/JAD-121348.
Performance monitoring tasks are suitable for investigating aging-related decline in executive functions. However, little is known about performance monitoring in premature pathological aging and mild cognitive impairment (MCI). This study recorded the error-related negativity (ERN) and the correct-related negativity (CRN) as indices of performance monitoring and compared these responses in older adults with MCI to the ones of younger and older adult controls. No differences in either ERN or CRN were found between younger and older adult controls. Compared to both control groups, we observed a more negatively pronounced CRN in MCI subjects. Only in this group did the amplitude of the CRN not differ from the one of the ERN. In general, larger differences between both components (i.e., ERN > CRN) were associated with better performances in cognitive tests requiring inhibition and executive control. These results indicate that electrophysiological correlates of performance monitoring (ERN and CRN) are differentially affected by aging and MCI.
绩效监测任务适合于研究与执行功能相关的衰老下降。然而，对于早产儿病理性衰老和轻度认知障碍（MCI）中的绩效监测知之甚少。本研究记录了错误相关负向电位（ERN）和正确相关负向电位（CRN）作为绩效监测的指标，并将 MCI 老年患者的这些反应与年轻和老年对照组进行了比较。在 ERN 或 CRN 方面，年轻和老年对照组之间没有差异。与两个对照组相比，我们观察到 MCI 患者的 CRN 更为负向。只有在这个组中，CRN 的振幅与 ERN 的振幅没有差异。一般来说，两个成分之间（即 ERN > CRN）的差异越大，与需要抑制和执行控制的认知测试的表现越好相关。这些结果表明，绩效监测的电生理相关性（ERN 和 CRN）受到衰老和 MCI 的不同影响。
