Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, 08907 Barcelona, Spain; Neuro-Oncology Unit, Hospital Universitari de Bellvitge-ICO L'Hospitalet-IDIBELL, 08907 Barcelona, Spain.
Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, 08907 Barcelona, Spain.
Neuroimage Clin. 2017 Dec 28;18:86-96. doi: 10.1016/j.nicl.2017.12.032. eCollection 2018.
No previous event-related potentials (ERPs) study has explored the error-related negativity (ERN) - an ERP component indexing performance monitoring - associated to cancer and chemotherapy-induced cognitive impairment in a lung cancer population. The aim of this study was to examine differences in performance monitoring in a small-cell lung cancer group (SCLC, C +) 1-month following chemotherapy and two control groups: a non-small cell lung cancer patient group (NSCLC, C -) prior to chemotherapy and a healthy control group (HC). Seventeen SCLC (C +) underwent a neuropsychological assessment and an ERP study using a flanker and a stop-signal paradigm. This group was compared to fifteen age-, gender- and education-matched NSCLC (C -) and eighteen HC. Between 20 and 30% of patients in both lung cancer groups (C + and C -) met criteria for cognitive impairment. Concerning ERPs, lung cancer patients showed lower overall hit rate and a severe ERN amplitude reduction compared to HC. Lung cancer patients exhibited an abnormal pattern of performance monitoring thus suggesting that chemotherapy and especially cancer itself, may contribute to cognitive deterioration. ERN appeared as an objective laboratory tool sensitive to cognitive dysfunction in cancer population.
以往的事件相关电位（ERP）研究尚未探讨错误相关负波（ERN）——一种评估绩效监测的 ERP 成分——与肺癌人群中的癌症和化疗引起的认知障碍之间的关系。本研究的目的是在小细胞肺癌组（SCLC，C+）化疗后 1 个月以及两个对照组：化疗前的非小细胞肺癌患者组（NSCLC，C-）和健康对照组（HC）中，检查绩效监测方面的差异。17 名 SCLC（C+）患者接受了神经心理学评估和 ERP 研究，使用了侧抑制和停止信号范式。将该组与 15 名年龄、性别和教育程度匹配的 NSCLC（C-）和 18 名 HC 进行比较。在这两个肺癌组（C+和 C-）中，有 20%至 30%的患者符合认知障碍标准。就 ERP 而言，与 HC 相比，肺癌患者的整体击中率较低，ERN 幅度明显降低。肺癌患者表现出异常的绩效监测模式，这表明化疗，特别是癌症本身，可能导致认知恶化。ERN 似乎是一种敏感的认知功能障碍的客观实验室工具，适用于癌症人群。
