Immune Cell Development and Host Defense, The Research Institute of Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.
Adv Exp Med Biol. 2013;785:77-86. doi: 10.1007/978-1-4614-6217-0_9.
Memory CD8⁺ T cells play an essential role in controlling pathogenic infections. Therefore generating protective memory CD8⁺ T cells by vaccination is an attractive strategy for preventing and treating a variety of human diseases. Understanding what comprises a protective memory CD8⁺ T cell response will help optimize vaccine-induced CD8⁺ T cell immunity. Here we discuss essential antiviral effector functions and highlight how recall expansion of memory CD8⁺ T cells may affect the primary response.
记忆性 CD8⁺ T 细胞在控制病原性感染方面发挥着重要作用。因此，通过接种疫苗产生保护性的记忆性 CD8⁺ T 细胞是预防和治疗多种人类疾病的一种有吸引力的策略。了解什么是保护性记忆性 CD8⁺ T 细胞反应将有助于优化疫苗诱导的 CD8⁺ T 细胞免疫。在这里，我们讨论了抗病毒的必需效应功能，并强调了记忆性 CD8⁺ T 细胞的回忆性扩增如何影响初次应答。
