Wildlife Disease Laboratories, Institute for Conservation Research, San Diego Zoo Global, PO Box 120551, San Diego, CA 92112-0551, USA.
Vet Pathol. 2013 May;50(3):443-50. doi: 10.1177/0300985813480511. Epub 2013 Mar 1.
Ten of 12 red-bellied short-necked turtles from a single clutch presented at 9 months of age with multiple white to tan nodules on their feet. Histologically, the nodules were composed of large periarticular deposits of mineralized crystalline material that extended into the joint spaces of interphalangeal joints and was surrounded by granulomatous inflammation and fibrosis. Crystallographic analysis determined the material to be apatite (calcium phosphate hydroxide) consistent with the tumoral calcinosis form of hydroxyapatite deposition disease (HADD). HADD has previously been described in aquatic turtles and rarely lizards and must be differentiated from gout in reptiles. A cause for the tumoral calcinosis lesions in these turtles could not be determined; however, based on previous reports in this species, a species-specific predilection, in conjunction with unknown environmental factors, is suspected. The use of the terms HADD, pseudogout (calcium pyrophosphate crystal deposition disease), and calcinosis circumscripta has been inconsistent, creating confusion in the literature.
12 只红腹短颈龟中的 10 只在 9 个月大时出现了多个白色到棕褐色的结节，分布在脚部。组织学上，这些结节由大量关节周围的矿化结晶物质组成，延伸到指间关节的关节间隙，并被肉芽肿性炎症和纤维化所包围。结晶分析确定该物质为磷灰石（磷酸氢钙），与羟磷灰石沉积病（HADD）的肿瘤性钙化形式一致。HADD 以前在水龟中很少在蜥蜴中被描述过，必须与爬行动物中的痛风相区别。这些龟的肿瘤性钙化病变的原因尚不清楚；然而，根据该物种的先前报告，怀疑是一种物种特有的倾向，加上未知的环境因素。HADD、假性痛风（焦磷酸钙晶体沉积病）和限局性钙化的术语使用一直不一致，在文献中造成了混淆。
