Department of Clinic Lab, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
J Basic Microbiol. 2014 Feb;54(2):111-9. doi: 10.1002/jobm.201200252. Epub 2013 Mar 1.
A majority of known eubacterial genomes are characteristic of GC skew, i.e., the leading strand has exceeding number of G over C. The cause of this compositional bias is still not very clear. In this study, we chose five pairs of genomes from distantly related bacterial genera, i.e., Buchnera, Haemophilus, Mycoplasma, Mycobacterium, and Synechococcus, each containing one with strong GC skew and the other with weak GC skew. Through comparison of the orthologous genes in these genera, we found that neither chromosomal rearrangement nor CDS skew has direct relationship with GC skew.
大多数已知的真细菌基因组都具有 GC 倾斜特征，即前导链的 G 含量超过 C。这种组成偏差的原因尚不清楚。在这项研究中，我们选择了五个来自远缘细菌属的基因组对，即 Buchnera、Haemophilus、Mycoplasma、Mycobacterium 和 Synechococcus，每个基因组对都包含一个 GC 倾斜较强的和一个 GC 倾斜较弱的基因组。通过比较这些属中的直系同源基因，我们发现染色体重排和 CDS 倾斜与 GC 倾斜没有直接关系。
