Lage Sergio, Andrade Fernando, Prieto José Angel, Asla Izaskun, Rodríguez Amaya, Ruiz Nerea, Echeverría Juncal, Luz Couce María, Sanjurjo Pablo, Aldámiz-Echevarría Luis
Department of Paediatrics, University of Basque Country, Bilbao, Spain.
J Pediatr Endocrinol Metab. 2013;26(1-2):53-60. doi: 10.1515/jpem-2012-0293.
The phosphocreatine/creatine system is fundamental for the proper development of the embryonic brain. Being born prematurely might alter the creatine biosynthesis pathway, in turn affecting creatine supply to the developing brain. We enrolled 53 preterm and very preterm infants and 55 full-term newborns. The levels of urinary guanidinoacetate, creatine, creatinine and amino acids were measured in the preterm and very preterm groups, 48 h and 9 days after birth and at discharge, and 48 h after birth in the full-term group. Guanidinoacetate concentrations of both preterm and very preterm newborns were significantly higher at discharge than the values for the full-term group at 48 h, while very preterm infants showed urinary creatine values significantly lower than those measured in the full-term group. Our results suggest an impairment of the creatine biosynthesis pathway in preterm and very preterm newborns, which could lead to creatine depletion affecting the neurological outcome in prematurely born infants.
磷酸肌酸/肌酸系统对胚胎大脑的正常发育至关重要。早产可能会改变肌酸生物合成途径，进而影响发育中大脑的肌酸供应。我们纳入了53名早产和极早产婴儿以及55名足月儿。在早产和极早产组出生后48小时、9天及出院时，以及足月儿组出生后48小时，测量尿中胍基乙酸、肌酸、肌酐和氨基酸的水平。早产和极早产新生儿出院时的胍基乙酸浓度显著高于足月儿组出生48小时时的值，而极早产婴儿的尿肌酸值显著低于足月儿组测量值。我们的结果表明，早产和极早产新生儿的肌酸生物合成途径受损，这可能导致肌酸耗竭，影响早产婴儿的神经学结局。
