端粒、癌症与衰老：长生不老？
Telomeres, cancer & aging: live long & prosper?
作者信息
Eissenberg Joel C
机构信息
Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, USA.
出版信息
Mo Med. 2013 Jan-Feb;110(1):11-6.
Abstract
Like our clothes, our chromosomes fray at the edges with age. Some believe that if we could discover a molecular tailor to patch our age-abraded chromosome ends, we could become modern Methuselahs. Notably, cancer cells achieve immortality by protecting their chromosome ends. Drugs that selectively fray the ends of cancer cell chromosomes would be potent and general anti-cancer therapies. Here, I summarize data on the role of chromosome ends in cellular and organismal aging.
摘要
如同我们的衣物，我们的染色体末端也会随着年龄增长而磨损。一些人认为，如果我们能找到一位分子裁缝来修补因年龄而磨损的染色体末端，我们就能成为现代的玛士撒拉（译注：《圣经》中最长寿的人）。值得注意的是，癌细胞通过保护其染色体末端来实现永生。能够选择性地磨损癌细胞染色体末端的药物将是强大而通用的抗癌疗法。在此，我总结了关于染色体末端在细胞和机体衰老中作用的数据。
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本文引用的文献
1
Telomeres and adversity: Too toxic to ignore.
Nature. 2012 Oct 11;490(7419):169-71. doi: 10.1038/490169a.
2
Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination.
Aging Cell. 2011 Oct;10(5):761-8. doi: 10.1111/j.1474-9726.2011.00718.x. Epub 2011 Jun 1.
3
Is telomere length a biomarker of aging? A review.
J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):202-13. doi: 10.1093/gerona/glq180. Epub 2010 Oct 28.
4
Telomeres and telomerase in cancer.
Carcinogenesis. 2010 Jan;31(1):9-18. doi: 10.1093/carcin/bgp268. Epub 2009 Nov 3.
5
The Stability of Broken Ends of Chromosomes in Zea Mays.
Genetics. 1941 Mar;26(2):234-82. doi: 10.1093/genetics/26.2.234.
6
The Behavior in Successive Nuclear Divisions of a Chromosome Broken at Meiosis.
Proc Natl Acad Sci U S A. 1939 Aug;25(8):405-16. doi: 10.1073/pnas.25.8.405.
7
The serial cultivation of human diploid cell strains.
Exp Cell Res. 1961 Dec;25:585-621. doi: 10.1016/0014-4827(61)90192-6.
8
Constitutive telomerase expression promotes mammary carcinomas in aging mice.
Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8191-6. doi: 10.1073/pnas.112515399. Epub 2002 May 28.
9
Telomere dysfunction and evolution of intestinal carcinoma in mice and humans.
Nat Genet. 2001 Jun;28(2):155-9. doi: 10.1038/88871.
10
Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis.
Nat Genet. 2000 Sep;26(1):114-7. doi: 10.1038/79089.
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