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本文引用的文献

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Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential.衰老与热量限制研究:具有转化潜力的生物学视角。
EBioMedicine. 2017 Jul;21:37-44. doi: 10.1016/j.ebiom.2017.06.015. Epub 2017 Jun 19.
2
From rapalogs to anti-aging formula.从雷帕霉素类似物到抗衰老配方。
Oncotarget. 2017 May 30;8(22):35492-35507. doi: 10.18632/oncotarget.18033.
3
Dietary protein, aging and nutritional geometry.饮食蛋白质、衰老与营养几何
Ageing Res Rev. 2017 Oct;39:78-86. doi: 10.1016/j.arr.2017.03.001. Epub 2017 Mar 6.
4
Convergence of Innate and Adaptive Immunity during Human Aging.人类衰老过程中固有免疫与适应性免疫的融合
Front Immunol. 2016 Nov 4;7:445. doi: 10.3389/fimmu.2016.00445. eCollection 2016.
5
Impact of intermittent fasting on health and disease processes.间歇性禁食对健康和疾病进程的影响。
Ageing Res Rev. 2017 Oct;39:46-58. doi: 10.1016/j.arr.2016.10.005. Epub 2016 Oct 31.
6
Resveratrol and Lifespan in Model Organisms.白藜芦醇与模式生物的寿命
Curr Med Chem. 2016;23(41):4639-4680. doi: 10.2174/0929867323666161024151233.
7
Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice.短暂的雷帕霉素治疗可延长中年小鼠的寿命并改善其健康状况。
Elife. 2016 Aug 23;5:e16351. doi: 10.7554/eLife.16351.
8
Calorie restriction in humans: An update.人类的热量限制:最新进展。
Ageing Res Rev. 2017 Oct;39:36-45. doi: 10.1016/j.arr.2016.08.005. Epub 2016 Aug 17.
9
Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health.减少支链氨基酸的摄入量可改善代谢健康。
Cell Rep. 2016 Jul 12;16(2):520-530. doi: 10.1016/j.celrep.2016.05.092. Epub 2016 Jun 23.
10
Metformin as a Tool to Target Aging.二甲双胍作为一种针对衰老的工具。
Cell Metab. 2016 Jun 14;23(6):1060-1065. doi: 10.1016/j.cmet.2016.05.011.

渴望不朽。

Hungering for Immortality.

作者信息

Eissenberg Joel C

机构信息

Joel C. Eissenberg, PhD, is a Professor and Associate Dean for Research, Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine.

出版信息

Mo Med. 2018 Jan-Feb;115(1):12-17.

PMID:30228670
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6139805/
Abstract

Beyond avoiding risky behavior-smoking, substance abuse, obesity-and embracing healthy habits like exercise, a balanced diet, and non-obese body weight, are there things we each do today to significantly extend our lifespan? Caloric restriction is the only behavioral intervention consistently shown to extend both mean and maximal lifespan across a wide range of species. In most cases, the lifespan extension is accompanied by a marked delay in the onset of age-associated disease and infirmity.

摘要

除了避免吸烟、药物滥用、肥胖等危险行为,并养成运动、均衡饮食和保持非肥胖体重等健康习惯外,我们今天每个人还能做些什么来显著延长寿命呢?热量限制是唯一一种在广泛物种中持续显示能延长平均寿命和最大寿命的行为干预措施。在大多数情况下,寿命延长伴随着与年龄相关疾病和虚弱的发病明显延迟。