糖衍生氮杂环丙烷硝酮的一般合成：氮杂环丙烷亚氨基糖的前体。
General synthesis of sugar-derived azepane nitrones: precursors of azepane iminosugars.
机构信息
Beijing National Laboratory of Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
出版信息
J Org Chem. 2013 Apr 5;78(7):3208-21. doi: 10.1021/jo400130p. Epub 2013 Mar 11.
PMID:23458237
Abstract
A general and efficient method has been developed for the synthesis of sugar-derived azepane nitrones starting from aldohexoses, with an intramolecular condensation of aldehyde and hydroxylamine as the key step. Through this strategy, each aldohexose produced a pair of azepane nitrones, which are precursors of various azepane iminosugars.
摘要
一种通用且高效的方法已经被开发出来，用于从醛糖起始合成糖衍生的氮杂环丁烷硝酮，其中醛和羟胺的分子内缩合是关键步骤。通过这种策略，每个醛糖都产生一对氮杂环丁烷硝酮，它们是各种氮杂环丁烷亚氨基糖的前体。
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