移植：共刺激阻断在移植中的前景。 - Suppr

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超能文献

Transplantation: The promise of co-stimulatory blockade in transplantation.

作者信息

Barth Rolf N, Bromberg Jonathan S

机构信息

University of Maryland School of Medicine, Division of Transplantation, Baltimore, MD 21201, USA.

出版信息

Nat Rev Nephrol. 2013 Apr;9(4):189-90. doi: 10.1038/nrneph.2013.37. Epub 2013 Mar 5.

DOI:10.1038/nrneph.2013.37

PMID:23458927

Abstract

摘要

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Transplantation: The promise of co-stimulatory blockade in transplantation.移植：共刺激阻断在移植中的前景。

Nat Rev Nephrol. 2013 Apr;9(4):189-90. doi: 10.1038/nrneph.2013.37. Epub 2013 Mar 5.

Belatacept.贝拉西普

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Transplantation and the CD28/CTLA4/B7 pathway.移植与CD28/CTLA4/B7信号通路

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Could expression of co-stimulatory molecules on B-PBL condition the acceptance or rejection of human liver grafts?B淋巴细胞来源的外周血淋巴细胞（B-PBL）上共刺激分子的表达会影响人肝移植的接受或排斥吗？

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Co-stimulatory molecules in islet xenotransplantation: CTLA4Ig treatment in CD40 ligand-deficient mice.胰岛异种移植中的共刺激分子：CD40配体缺陷小鼠的CTLA4Ig治疗

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CD28/CTLA-4 and CD80/CD86 costimulatory molecules are mainly involved in acceptance or rejection of human liver transplant.CD28/CTLA-4和CD80/CD86共刺激分子主要参与人类肝移植的接受或排斥反应。

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CD28-B7 T-cell co-stimulatory blockade potentiates the effects of intrathymic immunomodulation in sensitized graft recipients.CD28-B7共刺激阻断增强了致敏移植受者胸腺内免疫调节的效果。

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CD4-targeted therapy and CD28-B7 costimulatory blockage may independently induce tolerance in sensitized allograft recipients.靶向CD4的疗法和CD28-B7共刺激阻断可能分别诱导致敏同种异体移植受者产生免疫耐受。

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本文引用的文献

Belatacept and sirolimus prolong nonhuman primate renal allograft survival without a requirement for memory T cell depletion.贝伐珠单抗和西罗莫司延长非灵长类动物肾移植的存活期，而无需耗尽记忆 T 细胞。

Am J Transplant. 2013 Feb;13(2):320-8. doi: 10.1111/j.1600-6143.2012.04342.x. Epub 2013 Jan 11.

Belatacept and sirolimus prolong nonhuman primate islet allograft survival: adverse consequences of concomitant alefacept therapy.贝拉西普和西罗莫司延长非人类灵长类胰岛移植物的存活：同时使用阿法赛普治疗的不良后果。

Am J Transplant. 2013 Feb;13(2):312-9. doi: 10.1111/j.1600-6143.2012.04341.x. Epub 2012 Dec 27.

Three-year outcomes from BENEFIT, a randomized, active-controlled, parallel-group study in adult kidney transplant recipients.BENEFIT 研究：成人肾移植受者中一项随机、阳性对照、平行分组研究的 3 年结果。

Am J Transplant. 2012 Jan;12(1):210-7. doi: 10.1111/j.1600-6143.2011.03785.x. Epub 2011 Oct 12.

The risk and opportunity of homeostatic repopulation.内环境稳定再填充的风险与机遇。

Am J Transplant. 2011 Jul;11(7):1349-50. doi: 10.1111/j.1600-6143.2011.03543.x. Epub 2011 May 12.

Deciphering antibody-mediated rejection: new insights into mechanisms and treatment.解析抗体介导的排斥反应：对机制和治疗的新认识。

Curr Opin Organ Transplant. 2010 Feb;15(1):8-10. doi: 10.1097/MOT.0b013e3283342712.

Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells.调控调节者：共刺激信号控制调节性T细胞的稳态和功能。

Immunol Rev. 2009 May;229(1):41-66. doi: 10.1111/j.1600-065X.2009.00775.x.

Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties.LEA29Y（贝拉西普）的合理研发，一种具有强效免疫抑制特性的CTLA4-Ig高亲和力变体。

Am J Transplant. 2005 Mar;5(3):443-53. doi: 10.1111/j.1600-6143.2005.00749.x.

CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates.CTLA4免疫球蛋白和抗CD40配体可预防灵长类动物的肾移植排斥反应。

Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8789-94. doi: 10.1073/pnas.94.16.8789.

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways.阻断CD40和CD28信号通路后皮肤和心脏同种异体移植的长期存活

Nature. 1996 May 30;381(6581):434-8. doi: 10.1038/381434a0.

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