Centre for Cancer Biology, SA Pathology, Adelaide 5000, Australia.
Int J Biochem Cell Biol. 2013 Jun;45(6):1087-91. doi: 10.1016/j.biocel.2013.02.014. Epub 2013 Mar 1.
Neural crest cells are a transient population of stem cells that give rise to a diverse range of cell types during embryonic development. Through gain-of-function and loss-of-function studies in several model organisms many key signalling pathways and cell-type specific transcription factors essential for neural crest cell development have been identified. However, the role of post-translational regulation remains largely unexplored. Here we review this cell type with a foray into the known and potential roles of the ubiquitination pathway in key signalling events during neural crest cell development.
神经嵴细胞是一种短暂存在的干细胞群体，在胚胎发育过程中产生多种不同类型的细胞。通过在几种模式生物中进行功能获得和功能丧失研究，已经确定了许多对神经嵴细胞发育至关重要的关键信号通路和细胞类型特异性转录因子。然而，翻译后调控的作用在很大程度上仍未得到探索。本文综述了这一细胞类型，并探讨了泛素化途径在神经嵴细胞发育过程中的关键信号事件中的已知和潜在作用。
