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在体功能特性的球旁细胞在小鼠嗅球。

In vivo functional properties of juxtaglomerular neurons in the mouse olfactory bulb.

机构信息

Department of Physiology, Yale University New Haven, CT, USA ; NeuroImaging Cluster, Marine Biological Laboratory Woods Hole, MA, USA.

出版信息

Front Neural Circuits. 2013 Feb 21;7:23. doi: 10.3389/fncir.2013.00023. eCollection 2013.

DOI:10.3389/fncir.2013.00023
PMID:23459031
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3578271/
Abstract

Juxtaglomerular neurons represent one of the largest cellular populations in the mammalian olfactory bulb yet their role for signal processing remains unclear. We used two-photon imaging and electrophysiological recordings to clarify the in vivo properties of these cells and their functional organization in the juxtaglomerular space. Juxtaglomerular neurons coded for many perceptual characteristics of the olfactory stimulus such as (1) identity of the odorant, (2) odorant concentration, (3) odorant onset, and (4) offset. The odor-responsive neurons clustered within a narrow area surrounding the glomerulus with the same odorant specificity, with ~80% of responding cells located ≤20 μm from the glomerular border. This stereotypic spatial pattern of activated cells persisted at different odorant concentrations and was found for neurons both activated and inhibited by the odorant. Our data identify a principal glomerulus with a narrow shell of juxtaglomerular neurons as a basic odor coding unit in the glomerular layer and underline the important role of intraglomerular circuitry.

摘要

球旁神经元是哺乳动物嗅球中最大的细胞群体之一，但它们在信号处理中的作用尚不清楚。我们使用双光子成像和电生理记录来阐明这些细胞的体内特性及其在球旁空间中的功能组织。球旁神经元对嗅觉刺激的许多感知特征进行编码，例如（1）气味剂的身份，（2）气味剂浓度，（3）气味剂起始，和（4）气味剂结束。对气味有反应的神经元聚集在围绕着肾小球的一个狭窄区域内，具有相同的气味特异性，约 80%的反应细胞位于距肾小球边界≤20 μm 的位置。这种激活细胞的刻板的空间模式在不同的气味浓度下持续存在，并且在被气味激活和抑制的神经元中都被发现。我们的数据确定了一个主要的肾小球，其具有一个狭窄的球旁神经元壳，作为肾小球层中的基本气味编码单位，并强调了内肾小球电路的重要作用。

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Mitral cells in the olfactory bulb are mainly excited through a multistep signaling path.嗅球中的僧帽细胞主要通过多步信号通路被兴奋。
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