泛素结合酶 4 是一种衔接蛋白，可将泛素结合酶 1 招募到自噬机器中。
Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery.
机构信息
Department of Infectious Disease, South San Francisco, CA 94080, USA.
出版信息
EMBO Rep. 2013 Apr;14(4):373-81. doi: 10.1038/embor.2013.22. Epub 2013 Mar 5.
Abstract
Ubiquilins (Ubqlns)-a family of ubiquitin-binding proteins-are involved in several protein degradation pathways and have been implicated in various neurodegenerative diseases. Ubqln1 regulates autophagosome maturation during autophagy-mediated degradation. We now show that Ubqln4 mediates the interaction between Ubqln1 and the autophagy machinery by recruiting Ubqln1 to LC3. This targeting of Ubqln1 to autophagosomes requires the Ubqln4 UBL domain and the Ubqln1 UBA domain. This study identifies a new role for Ubqln4, expanding the role for Ubqlns in protein degradation.
摘要
泛素结合蛋白（Ubqlns）家族是一类与泛素结合的蛋白，参与多种蛋白降解途径，并与多种神经退行性疾病有关。Ubqln1 调控自噬体成熟过程中自噬介导的降解。我们现在表明 Ubqln4 通过将 Ubqln1 招募到 LC3 上来介导 Ubqln1 与自噬机制的相互作用。Ubqln1 靶向自噬体需要 Ubqln4 的 UBL 结构域和 Ubqln1 的 UBA 结构域。本研究确定了 Ubqln4 的一个新作用，扩展了 Ubqlns 在蛋白降解中的作用。
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