Kajita Yasukazu, Yoshida Kouta, Nagai Toshiya, Wakabayashi Toshihiko
Department of Neurosurgery, Nagoya University, School of Medicine, Japan.
No Shinkei Geka. 2013 Mar;41(3):209-18.
People with epilepsy have a high incidence of mood disorders that may affect their quality of life. Lamotrigine(LTG)is one of the antiepileptic drugs that are commercially available in Japan these days and its mood-stabilizing qualities were well known. First, 66 outpatients with epilepsy were evaluated for changes in mood states by the Profile of Mood States(POMS)and the Japanese-edition Beck Depression Inventory-Second Edition(BDI-II)on self report. The POMS questionnaire includes 30 items that address six components of mood. At baseline, one third of the outpatients with epilepsy had mood problems compared by POMS health reference. The mean BDI-II baseline score was 14.9±10.1, and one third of these epilepsy patients exhibited moderate or severe depression. Second, in the twelve patients with epilepsy, LTG was added to other antiepileptic drugs, and the POMS and BDI-II were administered at baseline and after addiction to LTG. 4 out of 8(50%)patients with simple partial seizure and 5 out of 8(62.5%)patients after the adjunctive therapy experienced at least a 50% reduction in the number of seizures compared with the self-reported baseline before the adjunctive therapy. The component scores of Depression-Dejection, Anger-Hostility and Confusion-Bewilderment in POMS were statistically improved in these patients completing adjunctive LTG(pared t-test, p<0.05). In these patients, the mean BDI-II baseline score was 25.8±13.1. Following administration of LTG, there was a significant decrease in the mean BDI-II scores(15.0±6.6)between baseline and the end of adjunctive LTG. This study suggests that, in addition to seizure control, LTG may have a mood-stabilizing effect and improve the quality of life in patients with epilepsy.
癫痫患者中情绪障碍的发生率较高，这可能会影响他们的生活质量。拉莫三嗪（LTG）是目前在日本市面上可买到的抗癫痫药物之一，其情绪稳定特性广为人知。首先，通过情绪状态剖面图（POMS）和日语版贝克抑郁量表第二版（BDI-II）对66例癫痫门诊患者进行自我报告的情绪状态变化评估。POMS问卷包含30个项目，涉及情绪的六个组成部分。在基线时，根据POMS健康参考标准，三分之一的癫痫门诊患者存在情绪问题。BDI-II基线平均得分是14.9±10.1，这些癫痫患者中有三分之一表现出中度或重度抑郁。其次，在12例癫痫患者中，将LTG添加到其他抗癫痫药物中，并在基线时以及添加LTG后进行POMS和BDI-II评估。与辅助治疗前自我报告的基线相比，8例单纯部分性发作患者中有4例（50%）以及辅助治疗后的8例患者中有5例（62.5%）癫痫发作次数至少减少了50%。在完成辅助LTG治疗的这些患者中，POMS中抑郁-沮丧、愤怒-敌意和困惑-迷茫的分量表得分有统计学意义的改善（配对t检验，p<0.05）。在这些患者中，BDI-II基线平均得分是25.8±13.1。服用LTG后，基线与辅助LTG治疗结束时的BDI-II平均得分有显著下降（15.0±6.6）。这项研究表明，除了控制癫痫发作外，LTG可能具有情绪稳定作用，并改善癫痫患者的生活质量。
