Park C, Cho N H, Jeong H J
Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Med J. 1990 Mar;31(1):27-32. doi: 10.3349/ymj.1990.31.1.27.
We compared the pigment of melanosis coli with the pigment of Dubin-Johnson syndrome, melanin, and lipofuscin. The pigment of melanosis coli appeared similar to lipofuscin in that it stained positively with periodic acid-Schiff, oil red-0 and Victoria blue stains and revealed negative reactions to the immunohistochemical stains for S-100 protein and neuron specific enolase, but had similarity to melanin as shown by the positive reaction to Fontana-Masson stain and negative autofluorescence. The pigment of Dubin-Johnson syndrome showed the same histochemical and immunohistochemical characteristics as that of melanosis coli. The results indicate that the pigments of melanosis coli and Dubin-Johnson syndrome are identical and are variants of lipofuscin.
我们将结肠黑变病的色素与杜宾-约翰逊综合征的色素、黑色素和脂褐素进行了比较。结肠黑变病的色素与脂褐素相似，它对过碘酸-希夫染色、油红-O染色和维多利亚蓝染色呈阳性反应，对S-100蛋白和神经元特异性烯醇化酶的免疫组织化学染色呈阴性反应，但与黑色素相似，对Fontana-Masson染色呈阳性反应且自发荧光呈阴性。杜宾-约翰逊综合征的色素显示出与结肠黑变病相同的组织化学和免疫组织化学特征。结果表明，结肠黑变病和杜宾-约翰逊综合征的色素是相同的，是脂褐素的变体。
