Belonovskaia E B, Naruta E E, Lukivskaia O Ia, Abakumov V Z, Buko V U
Eksp Klin Farmakol. 2013;76(1):25-9.
We have studied the prophylactic effect of new derivatives of ursodeoxycholic acid (UDCA), including UDCA-N-acetylcysteine, UDCA-L-acetylcysteine, and nor-UDCA (in doses equivalent to 40 mg/kg of UDCA) on the development of experimental alcoholic steatohepatitis induced by the Lieber-DeCarli liquid ethanol-containing diet. Results demonstrated that most of the investigated compounds produced a hepatoprotective effect, improving biochemical tests and liver morphology, as manifested by decreasing steatosis intensity, activity of alkaline phosphatase and gamma-glutamyltranspeptidase, triglyceride level in blood serum and liver, and TNF alpha content. However, nor-UDCA was most effective as compared to UDCA in preventing the accumulation of triglycerides in the liver.
我们研究了熊去氧胆酸（UDCA）的新衍生物，包括UDCA-N-乙酰半胱氨酸、UDCA-L-乙酰半胱氨酸和去氢熊去氧胆酸（剂量相当于40mg/kg的UDCA）对由含乙醇的Lieber-DeCarli液体饮食诱导的实验性酒精性脂肪性肝炎发展的预防作用。结果表明，大多数研究的化合物产生了肝保护作用，改善了生化检测和肝脏形态，表现为脂肪变性强度降低、碱性磷酸酶和γ-谷氨酰转肽酶活性降低、血清和肝脏中的甘油三酯水平降低以及TNFα含量降低。然而，与UDCA相比，去氢熊去氧胆酸在预防肝脏中甘油三酯积累方面最有效。
