Gambelunghe Cristiana, Rossi Riccardo, Aroni Kyriaki, Bacci Mauro, Lazzarini Andrea, De Giovanni Nadia, Carletti Paola, Fucci Nadia
Department of Clinical and Experimental Medicine, Division of Legal and Sports Medicine, University of Perugia, Padiglione W, via E. Dal Pozzo, 06126 Perugia, Italy.
Ann Clin Lab Sci. 2013 Winter;43(1):22-30.
It may be advantageous to use sweat, rather than blood or urine, to monitor individuals' drug exposure for the purposes of drug treatment programs, employment initiatives, and forensic investigations. Forty-eight patients receiving methadone at the Public Service for the Treatment of Drug Dependence of Perugia (Italy) were monitored for 14 days by the analysis of methadone and cocaine present in two sweat patches, each worn for 7 days. The results were compared to those from the analysis of urine samples collected at the beginning of the study and after 7 days, as well as those from the analysis of hair collected on the fourteenth day. Sweat patch analysis was positive for methadone and its metabolite EDDP in 100% of patients. Some individuals were positive for cocaine in urine, sweat, and hair while others were positive for cocaine in only one of those samples. Results suggest analysis of a sweat patch indicates an individual's drug use or drug washout for the previous week, and provides an alternative to blood or urine analyses.
为了药物治疗项目、就业计划和法医调查的目的，使用汗液而非血液或尿液来监测个体的药物暴露情况可能具有优势。在意大利佩鲁贾药物依赖治疗公共服务中心接受美沙酮治疗的48名患者，通过分析两个汗液贴片（每个佩戴7天）中存在的美沙酮和可卡因而被监测了14天。将结果与研究开始时和7天后收集的尿液样本分析结果以及第14天收集的毛发分析结果进行了比较。汗液贴片分析显示，100%的患者美沙酮及其代谢物EDDP呈阳性。一些个体的尿液、汗液和毛发中可卡因呈阳性，而另一些个体仅在其中一个样本中可卡因呈阳性。结果表明，对汗液贴片的分析表明了个体在前一周的药物使用或药物清除情况，并提供了一种替代血液或尿液分析的方法。
