Smith Laura, Minter Steve, O'Brien Paul, Kraveka Jacqueline M, Medina Ana Maria, Lazarchick John
Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA.
Ann Clin Lab Sci. 2013 Winter;43(1):81-4.
Neuroblastoma is the most common malignancy in children less than one year of age, but is rare in adults. Adult neuroblastoma differs from pediatric cases by lacking classical features including low incidence of MYCN amplification, elevated urinary catecholamimes, and MIBG avidity. The diagnosis may not be initially considered because of the rarity, which emphasizes the importance of immunohistochemical staining and cytogenetic testing in aiding the diagnosis. We present a case of neuroblastoma in a 39-year-old woman who failed to respond to intensive therapy for this malignancy and died within a year after diagnosis.
神经母细胞瘤是一岁以下儿童最常见的恶性肿瘤，但在成人中罕见。成人神经母细胞瘤与儿童病例不同，缺乏经典特征，包括MYCN扩增发生率低、尿儿茶酚胺升高和间碘苄胍（MIBG）摄取。由于其罕见性，最初可能不会考虑该诊断，这凸显了免疫组织化学染色和细胞遗传学检测在辅助诊断中的重要性。我们报告一例39岁女性神经母细胞瘤病例，该患者对此恶性肿瘤的强化治疗无反应，诊断后一年内死亡。
