Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Acta Derm Venereol. 2013 Jul 6;93(4):387-93. doi: 10.2340/00015555-1557.
Hypothalamic-pituitary-adrenal (HPA) axis hormones and their receptors expressed in the skin are known to function locally, but how these hormones affect the maintenance of skin homeostasis or the pathogenesis of skin diseases is not fully understood. We comprehensively reviewed the distribution and function of the central and peripheral HPA axis in various stress-related skin diseases. Previous studies have shown altered expression of central and peripheral HPA axis hormones in chronic inflammatory skin diseases and skin tumours, and that hyper-active lesional HPA axis hormones may negatively feedback to the central HPA axis and interact with some cytokines and neuropeptides, leading to symptom deterioration. This provides an evidence-based understanding of the expression of the central and peripheral HPA axis in common skin diseases and its association with disease activity.
已知下丘脑-垂体-肾上腺 (HPA) 轴激素及其在皮肤中表达的受体在局部发挥作用，但这些激素如何影响皮肤稳态的维持或皮肤病的发病机制尚不完全清楚。我们全面回顾了中枢和外周 HPA 轴在各种与应激相关的皮肤疾病中的分布和功能。先前的研究表明，慢性炎症性皮肤病和皮肤肿瘤中中枢和外周 HPA 轴激素的表达发生改变，活性过高的病灶 HPA 轴激素可能会对中枢 HPA 轴产生负反馈，并与一些细胞因子和神经肽相互作用，导致症状恶化。这为理解常见皮肤病中中枢和外周 HPA 轴的表达及其与疾病活动的关系提供了循证依据。
